Efficacy and safety of Resina Draconis for wound repair in the treatment of diabetic foot ulcer: A systematic review and meta-analysis of randomized controlled trials

被引：7
作者：
Feng, Haoyue [1 ]
Huang, Wenhui [1 ]
Zhou, Qi [2 ]
Liu, Tianyi [3 ]
Li, Hui [4 ]
Yue, Rensong [1 ]
机构：
[1] Hosp Chengdu Univ Tradit Chinese Med, Chengdu, Peoples R China
[2] Chengdu Univ Tradit Chinese Med, Chengdu, Peoples R China
[3] Chongqing Fuling Peoples Hosp, Chongqing, Peoples R China
[4] Sichuan Acupuncture & Moxibust Sch, Chengdu, Peoples R China
来源：
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE | 2023年 / 50卷
关键词：
Diabetic foot ulcer; Meta-analysis; Randomized controlled trials; Resina draconis; Systematic review; COMPONENTS;
D O I：
10.1016/j.ctcp.2022.101707
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Background and purpose: Resina Draconis (RD) is widely used to treat topical skin ulcers. However, its effect on diabetic foot ulcer (DFU) remains unknown. The present meta-analysis aims to evaluate the efficacy and safety of RD for wound healing in DFU treatment. Methods: Literature searches were conducted with databases including PubMed, Embase, Cochrane Library, the China National Knowledge Infrastructure, the Wanfang Database, the Database for Chinese Technical Periodicals, and the China Biology Medicine Disc. Relevant studies were selected based on specified inclusion and exclusion criteria. Software RevMan 5.4 was used for study selection, quality assessment, and data analysis, while the Cochrane Risk of Bias (RoB) 2.0 tool was used to assess RoB. Results: Nine eligible randomized controlled trials (RCTs), involving 679 patients, were included in this review. The results showed that the healing time of the RD group was shorter than that of the control group (P < 0.00001), while the RD group also presented a higher healing rate (P < 0.0001), a higher rate of ulcer area reduction (P = 0.0005), and a higher rate in the patients with a reduced Wagner grade (P = 0.002). Simulta-neously, a lower frequency of dressing changes (P < 0.00001) and a shorter length of hospital stays (P < 0.00001) are the characteristics of the RD group as well. Conclusion: The treatment with RD is a safe and effective solution for DFU, and its combination with conventional treatment can improve the healing rate of DFU, reduce healing time, and inhibit further development. However, owing to the limited quality and quantity of included studies, further high-quality research is necessary to support these conclusions.
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页数：10
相关论文
共 54 条
[11]  
[王俊 Wang Jun], 2021, [中华糖尿病杂志, Chinese Journal of Diabetes Mellitus], V13, P449
[12]   Clinician Assessment Tools for Patients with Diabetic Foot Disease: A Systematic Review [J].
Fernandez-Torres, Raul ;
Ruiz-Munoz, Maria ;
Perez-Panero, Alberto J. ;
Garcia-Romero, Jeronimo C. ;
Gonzalez-Sanchez, Manuel .
JOURNAL OF CLINICAL MEDICINE, 2020, 9 (05)
[13]   GRADE:: an emerging consensus on rating quality of evidence and strength of recommendations [J].
Guyatt, Gordon H. ;
Oxman, Andrew D. ;
Vist, Gunn E. ;
Kunz, Regina ;
Falck-Ytter, Yngve ;
Alonso-Coello, Pablo ;
Schuenemann, Holger J. .
BRITISH MEDICAL JOURNAL, 2008, 336 (7650) :924-926
[14]  
He X, 2011, NEW CHIN MED, V43, P144, DOI [10.13457/j.cnki.jncm.2011.08.072, DOI 10.13457/J.CNKI.JNCM.2011.08.072]
[15]  
He X.L., 2010, J TRADIT CHIN MED U, V30, P23, DOI [10.3969/j.issn.1674-070X.2010.11.007.023.03, DOI 10.3969/J.ISSN.1674-070X.2010.11.007.023.03]
[16]  
He X.L., 2010, TRADIT CHIN MED U HU
[17]  
Hu B., 2015, CHIN NURS RES, V29, P1639, DOI [10.3969/j.issn.10096493.2015.13.03, DOI 10.3969/J.ISSN.10096493.2015.13.03]
[18]  
Huang Z.D., 2008, CHIN J INF TRADIT CH, V15, P72, DOI [10.3969/j.issn.1005-5304.2008.07.040, DOI 10.3969/J.ISSN.1005-5304.2008.07.040]
[19]  
International Diabetes Federation, 2005, TIM ACT DIAB FOOT CA
[20]  
Khalafallah A, 2010, MEDITERR J HEMATOL I, V2, DOI [10.4084/MJHID.2010.005, 10.1136/bmj.l4898]
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