Post-tuberculosis sequelae in children and adolescents: a systematic review

被引:24
作者
Igbokwe, Vanessa [1 ]
Ruby, Lisa C. [2 ,3 ,4 ]
Sultanli, Ayten [5 ,6 ]
Belard, Sabine [5 ,6 ]
机构
[1] Charite Univ Med Berlin, Dept Pediat Resp Med Immunol & Crit Care Med, Berlin, Germany
[2] Charite, Dept Infect Dis & Resp Med, Berlin, Germany
[3] Free Univ Berlin, Berlin, Germany
[4] Humboldt Univ, Berlin, Germany
[5] Univ Tubingen, Inst Trop Med, D-72074 Tubingen, Germany
[6] German Ctr Infect Res, Tubingen, Germany
关键词
POSTERIOR FOCUS DEBRIDEMENT; TERM-FOLLOW-UP; SOLITARY CYSTIC TUBERCULOSIS; SPINAL TUBERCULOSIS; SURGICAL-TREATMENT; PULMONARY TUBERCULOSIS; NATURAL-HISTORY; CERVICAL-SPINE; LUMBAR SPINE; HONG-KONG;
D O I
10.1016/S1473-3099(23)00004-X
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
In 2020, an estimated total of 155 million people had survived tuberculosis. Among this number, a sizable proportion have considerable post-tuberculosis morbidity, as shown for the adult population. This systematic review aims to identify the spectrum and prevalence of post-tuberculosis sequelae in children and adolescents. Four databases were systematically searched from database inception to Feb 7, 2022, for literature on post-treatment outcomes of tuberculosis acquired during childhood. Of the 4613 identified publications, 71 studies were included in this systematic review. Studies on cohorts with comparably rare (most of which were extrapulmonary) tuberculosis presentations, such as spinal tuberculosis and tuberculous meningitis were over-represented; however, no study assessed long-term sequelae in a cohort with an average childhood tuberculosis spectrum. The descriptive analysis includes long-term outcomes of 3529 paediatric patients 1 month to 36 years after confirmed (47%) or clinical (53%) tuberculosis. In a considerable proportion of children, a broad spectrum of post-tuberculosis sequelae were identified, ranging from radiological residua after pulmonary tuberculosis, to disabling deformities after musculoskeletal and cutaneous tuberculosis, to somatic and psychosocial impairment after tuberculous meningitis. A better understanding and comprehensive assessment of post-tuberculosis sequelae in children are needed to improve tuberculosis care beyond antituberculous treatment.
引用
收藏
页码:E138 / E150
页数:13
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