Recent advances in mesenchymal stem/stromal cells (MSCs)-based approaches for osteoarthritis (OA) therapy

被引：13

作者：

Hassanzadeh, Ali ^{[1
]}

Vousooghi, Nasim ^{[1
]}

Rahimnia, Ramin ^{[2
]}

Razeghian, Ehsan ^{[3
]}

Rajaeian, Simin ^{[1
]}

Seyhoun, Iman ^{[1
]}

Sharif, Shiva ^{[1
,4
]}

Verdi, Javad ^{[1
,4
]}

机构：

[1] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Appl Cell Sci, Tehran, Iran

[2] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Med Nanotechnol, Tehran, Iran

[3] Natl Inst Genet Engn & Biotechnol NIGEB, Dept Med Biotechnol, Div Human Genet, Tehran, Iran

[4] Univ Tehran Med Sci, Res Ctr War affected People, Tehran, Iran

来源：

CELL BIOLOGY INTERNATIONAL | 2023年 / 47卷 / 06期

关键词：

chondrocyte; immunomodulation; mesenchymal stem; stromal cells (MSCs); osteoarthritis (OA); transplantation; PROOF-OF-CONCEPT; STEM-CELLS; BONE-MARROW; KNEE OSTEOARTHRITIS; CHONDROGENIC DIFFERENTIATION; SUPERFICIAL LAYER; CARTILAGE REPAIR; CLINICAL-TRIAL; INFLAMMATION; EXOSOMES;

D O I：

10.1002/cbin.12008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recently, mesenchymal stem/stromal cells (MSCs) transplantation has been introduced as a promising option to support cartilage structure and improve its function in preclinical models and patients suffering from osteoarthritis (OA). MSCs strongly provoke their preferred influence in vivo by inhibiting the inflammatory responses and applying immunomodulation by releasing anti-inflammatory mediators such as transforming growth factor-beta and interleukin-10. Such mediators downregulate fibroblast-like synoviocytes growth and migration, leading to chondroprotection. Furthermore, improving the chondrocyte proliferation and extracellular matrix hemostasis in addition to the suppression of the matrix metalloproteinases activities can support cartilage tissue organization. In this light, various published results have demonstrated that MSCs therapy can considerably decrease pain and restore knee function in OA patients. In the current review, we have concentrated on recent advances in MSCs-based therapeutics to elicit both chondrogenic and chondroprotective impacts in OA patients, focusing on the last decade in vivo results.

引用

页码：1033 / 1048

页数：16

共 165 条

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