Association of PNPLA3 SNP With the Development of HBV-related Hepatocellular Carcinoma

被引:2
作者
Enomoto, Hirayuki [1 ,2 ]
Aizawa, Nobuhiro [1 ]
Ikeda, Naoto [1 ]
Takashima, Tomoyuki [1 ]
Yuri, Yukihisa [1 ]
Okamoto, Mamiko [1 ]
Yoshioka, Ryota [1 ]
Kawata, Shoki [1 ]
Yoshihara, Kohei [1 ]
Ota, Shogo [1 ]
Nakano, Ryota [1 ]
Shiomi, Hideyuki [1 ]
Nishimura, Takashi [1 ]
Iijima, Hiroko [1 ]
机构
[1] Hyogo Med Univ, Dept Internal Med, Div Hepatobiliary & Pancreat Dis, Nishinomiya, Japan
[2] Hyogo Med Univ, Dept Internal Med, Div Hepatobiliary & Pancreat Dis, Mukogawa Cho1-1, Nishinomiya, Hyogo 6638501, Japan
来源
IN VIVO | 2023年 / 37卷 / 02期
关键词
HBV; hepatocellular carcinoma; hepatic steatosis; HOMA-IR; PNPLA3; LIVER; STEATOSIS; IMPACT;
D O I
10.21873/invivo.13139
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Background/Aim: Concomitant nonalcoholic fatty liver disease (NAFLD)/hepatic steatosis (HS) is suggested to increase the risk of hepatocellular carcinoma (HCC) in hepatitis virus B (HBV)-infected patients. Patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 gene single-nucleotide polymorphism (SNP) is well-known to be associated with the development of NAFLD/HS; however, it is still unclear whether this SNP is related to the development of HCC in HBV-infected patients. Patients and Methods: We investigated a total of 202 HBV-infected patients who received percutaneous liver biopsy, and simultaneously assessed biopsy-proven HS, insulin resistance, and the PNPLA3 SNP status. We further investigated the relationships of these factors with the development of HCC in HBV-infected patients. Results: Most of the enrolled cases (196/202: 97.0%) were non-cirrhotic patients. One hundred seventy-three patients (85.6%) received antiviral therapy. A Kaplan-Meier analysis showed that the incidence of HCC development in patients with HS was higher than that in patients without HS (p<0.01). An increased homeostasis model assessment as an index of insulin resistance (HOMA-IR) value (>= 1.6) was associated not only with the presence of HS (p<0.0001) but also with the development of HCC (p<0.01). The PNPLA3 rs738409 SNP was also associated with the presence of HS (p<0.01) and the development of HCC (p<0.05) in HBV-infected patients. Conclusion: In addition to HS and IR, PNPLA3 rs738409 SNP was suggested to be associated with the development of HCC in Japanese patients with HBV infection.
引用
收藏
页码:763 / 770
页数:8
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