Outcome measures for Alzheimer's disease: A global inter-societal Delphi consensus

被引：9

作者：

Ellison, Tim S. ^{[1
]}

Cappa, Stefano F. ^{[2
,3
]}

Garrett, Dawne ^{[4
]}

Georges, Jean ^{[5
]}

Iwatsubo, Takeshi ^{[6
,7
]}

Kramer, Joel H. ^{[8
]}

Lehmann, Maryna ^{[9
]}

Lyketsos, Constantine ^{[10
]}

Maier, Andrea B. ^{[11
,12
,13
,14
]}

Merrilees, Jennifer

Morris, John C. ^{[15
]}

Naismith, Sharon L. ^{[16
]}

Nobili, Flavio ^{[17
,18
]}

Pahor, Marco ^{[19
]}

Pond, Dimity ^{[20
]}

Robinson, Louise ^{[21
]}

Soysal, Pinar ^{[22
,23
]}

Vandenbulcke, Mathieu ^{[24
,25
]}

Weber, Christopher J. ^{[26
]}

Visser, Pieter Jelle ^{[27
,28
,29
]}

Weiner, Michael ^{[30
,31
]}

Frisoni, Giovanni B. ^{[32
,33
,34
]}

机构：

[1] PharmaGenesis London, London, England

[2] Scuola Univ Super IUSS Pavia, Pavia, Italy

[3] IRCCS Mondino Fdn, Dementia Res Ctr, Pavia, Italy

[4] Royal Coll Nursing UK, London, England

[5] Alzheimer Europe, Luxembourg, Luxembourg

[6] Univ Tokyo Hosp, Unit Early & Exploratory Clin Dev, Tokyo, Japan

[7] Univ Tokyo, Grad Sch Med, Dept Neuropathol, Tokyo, Japan

[8] Univ Calif San Francisco, Memory & Aging Ctr, Dept Neurol, San Francisco, CA USA

[9] World Dementia Council, George, South Africa

[10] Johns Hopkins Univ & Med, Richman Family Precis Med Ctr Excellence Alzheime, Dept Psychiat & Behav Sci, Baltimore, MD USA

[11] Univ Melbourne, Royal Melbourne Hosp, Dept Med & Aged Care, Melbourne, Vic, Australia

[12] Vrije Univ, Fac Behav & Movement Sci, Dept Human Movement Sci, Amsterdam Movement Sci, Amsterdam, Netherlands

[13] Natl Univ Singapore, Yong Loo Lin Sch Med, Hlth Longev Translat Res Program, Singapore, Singapore

[14] Natl Univ Hlth Syst, Ctr Hlth Longev, Singapore, Singapore

[15] Washington Univ, Dept Neurol, St Louis, MO USA

[16] Univ Sydney, Sch Psychol, Sydney, NSW, Australia

[17] Ist Ricovero & Cura Carattere Sci Osped Policlin, UO Clin Neurol, Genoa, Italy

[18] Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet & Child &, Genoa, Italy

[19] Univ Florida, Inst Aging, Dept Aging & Geriatr Res, Coll Med, Gainesville, FL USA

[20] Univ Newcastle, Fac Hlth & Med, Sch Med & Publ Hlth, Newcastle, NSW, Australia

[21] Newcastle Univ, Populat Hlth Sci Inst, Newcastle Upon Tyne, Tyne & Wear, England

[22] Bezmialem Vakif Univ, Fac Med, Dept Geriatr Med, Istanbul, Turkiye

[23] European Soc Geriatr Med, Dementia Special Interest Grp, London, England

[24] Katholieke Univ Leuven, Leuven Brain Inst, Dept Neurosci, Neuropsychiat, Leuven, Belgium

[25] Katholieke Univ Leuven, Geriatr Psychiat, Univ Psychiat Ctr, Leuven, Belgium

[26] Alzheimers Assoc, Chicago, IL USA

[27] Maastricht Univ, Sch Mental Hlth & Neurosci MHeNS, Dept Psychiat & Neuropsychol, Maastricht, Netherlands

[28] Univ Amsterdam, Alzheimer Ctr, VU Med Ctr, Dept Neurol,Med Ctr, Neurosci Campus Amsterdam, Amsterdam, Netherlands

[29] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden

[30] San Francisco VA Med Ctr, San Francisco, CA USA

[31] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA USA

[32] Univ Geneva, Lab Neuroimaging Aging LANVIE, Geneva, Switzerland

[33] Univ Geneva, Dept Readaptat & Geriatr, Memory Clin, Geneva, Switzerland

[34] Univ Hosp, Geneva, Switzerland

来源：

ALZHEIMERS & DEMENTIA | 2023年

关键词：

Alzheimer's disease; consensus; Delphi; dementia; measures; outcomes; MILD COGNITIVE IMPAIRMENT; QUALITY-OF-LIFE; FUNCTIONAL-ACTIVITIES QUESTIONNAIRE; DAILY LIVING SCALE; REVISED ACE-R; INSTRUMENTAL-ACTIVITIES; NEUROPSYCHIATRIC INVENTORY; DEPRESSION SCALE; OLDER-ADULTS; CORNELL SCALE;

D O I：

10.1002/alz.12945

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

IntroductionWe aim to provide guidance on outcomes and measures for use in patients with Alzheimer's clinical syndrome. MethodsA consensus group of 20 voting members nominated by 10 professional societies, and a non-voting chair, used a Delphi approach and modified GRADE criteria. ResultsConsensus was reached on priority outcomes (n = 66), measures (n = 49) and statements (n = 37) across nine domains. A number of outcomes and measurement instruments were ranked for: Cognitive abilities; Functional abilities/dependency; Behavioural and neuropsychiatric symptoms; Patient quality of life (QoL); Caregiver QoL; Healthcare and treatment-related outcomes; Medical investigations; Disease-related life events; and Global outcomes. DiscussionThis work provides indications on the domains and ideal pertinent measurement instruments that clinicians may wish to use to follow patients with cognitive impairment. More work is needed to develop instruments that are more feasible in the context of the constraints of clinical routine.

引用

页码：2707 / 2729

页数：23

共 127 条

[21] Mini-Mental State Examination (MMSE) for the detection of dementia in clinically unevaluated people aged 65 and over in community and primary care populations
Creavin, Sam T.
Wisniewski, Susanna
Noel-Storr, Anna H.
Trevelyan, Clare M.
Hampton, Thomas
Rayment, Dane
Thom, Victoria M.
Nash, Kirsty J. E.
Elhamoui, Hosam
Milligan, Rowena
Patel, Anish S.
Tsivos, Demitra V.
Wing, Tracey
Phillips, Emma
Kellman, Sophie M.
Shackleton, Hannah L.
Singleton, Georgina F.
Neale, Bethany E.
Watton, Martha E.
Cullum, Sarah
[J]. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2016, (01):
[22] The performance of instrumental-activities of daily living scale in screening for cognitive impairment in elderly community residents
Cromwell, DA
Eagar, K
Poulos, RG
[J]. JOURNAL OF CLINICAL EPIDEMIOLOGY, 2003, 56 (02) : 131 - 137
[23] Screening for dementia in an Irish community sample using MMSE: a comparison of norm-adjusted versus fixed cut-points
Cullen, B
Fahy, S
Cunningham, CJ
Coen, RF
Bruce, I
Greene, E
Coakley, D
Walsh, JB
Lawlor, BA
[J]. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 2005, 20 (04) : 371 - 376
[24] The neuropsychiatric inventory: Assessing psychopathology in dementia patients
Cummings, JL
[J]. NEUROLOGY, 1997, 48 (05) : S10 - S16
[25] THE NEUROPSYCHIATRIC INVENTORY - COMPREHENSIVE ASSESSMENT OF PSYCHOPATHOLOGY IN DEMENTIA
CUMMINGS, JL
MEGA, M
GRAY, K
ROSENBERGTHOMPSON, S
CARUSI, DA
GORNBEIN, J
[J]. NEUROLOGY, 1994, 44 (12) : 2308 - 2314
[26] Cerebral Amyloid-β Deposition Is Associated with Impaired Gait Speed and Lower Extremity Function
Dao, Elizabeth
Hsiung, Ging-Yuek Robin
Sossi, Vesna
Tam, Roger
Shahinfard, Elham
Nicklin, Eloise
Al Keridy, Walid
Liu-Ambrose, Teresa
[J]. JOURNAL OF ALZHEIMERS DISEASE, 2019, 71 : S41 - S49
[27] Montreal Cognitive Assessment for the detection of dementia
Davis, Daniel H. J.
Creavin, Samuel T.
Yip, Jennifer L. Y.
Noel-Storr, Anna H.
Brayne, Carol
Cullum, Sarah
[J]. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2021, (07):
[28] Davis KL, 1997, INT J GERIATR PSYCH, V12, P978, DOI 10.1002/(SICI)1099-1166(199710)12:10<978::AID-GPS659>3.0.CO
[29] 2-1
[30] Exploring the experiences of people with mild cognitive impairment and their caregivers with particular reference to healthcare - a qualitative study
Dean, Katherine
Jenkinson, Crispin
Wilcock, Gordon
Walker, Zuzana
[J]. INTERNATIONAL PSYCHOGERIATRICS, 2014, 26 (03) : 475 - 485

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