Outcome measures for Alzheimer's disease: A global inter-societal Delphi consensus

被引：9

作者：

Ellison, Tim S. ^{[1
]}

Cappa, Stefano F. ^{[2
,3
]}

Garrett, Dawne ^{[4
]}

Georges, Jean ^{[5
]}

Iwatsubo, Takeshi ^{[6
,7
]}

Kramer, Joel H. ^{[8
]}

Lehmann, Maryna ^{[9
]}

Lyketsos, Constantine ^{[10
]}

Maier, Andrea B. ^{[11
,12
,13
,14
]}

Merrilees, Jennifer

Morris, John C. ^{[15
]}

Naismith, Sharon L. ^{[16
]}

Nobili, Flavio ^{[17
,18
]}

Pahor, Marco ^{[19
]}

Pond, Dimity ^{[20
]}

Robinson, Louise ^{[21
]}

Soysal, Pinar ^{[22
,23
]}

Vandenbulcke, Mathieu ^{[24
,25
]}

Weber, Christopher J. ^{[26
]}

Visser, Pieter Jelle ^{[27
,28
,29
]}

Weiner, Michael ^{[30
,31
]}

Frisoni, Giovanni B. ^{[32
,33
,34
]}

机构：

[1] PharmaGenesis London, London, England

[2] Scuola Univ Super IUSS Pavia, Pavia, Italy

[3] IRCCS Mondino Fdn, Dementia Res Ctr, Pavia, Italy

[4] Royal Coll Nursing UK, London, England

[5] Alzheimer Europe, Luxembourg, Luxembourg

[6] Univ Tokyo Hosp, Unit Early & Exploratory Clin Dev, Tokyo, Japan

[7] Univ Tokyo, Grad Sch Med, Dept Neuropathol, Tokyo, Japan

[8] Univ Calif San Francisco, Memory & Aging Ctr, Dept Neurol, San Francisco, CA USA

[9] World Dementia Council, George, South Africa

[10] Johns Hopkins Univ & Med, Richman Family Precis Med Ctr Excellence Alzheime, Dept Psychiat & Behav Sci, Baltimore, MD USA

[11] Univ Melbourne, Royal Melbourne Hosp, Dept Med & Aged Care, Melbourne, Vic, Australia

[12] Vrije Univ, Fac Behav & Movement Sci, Dept Human Movement Sci, Amsterdam Movement Sci, Amsterdam, Netherlands

[13] Natl Univ Singapore, Yong Loo Lin Sch Med, Hlth Longev Translat Res Program, Singapore, Singapore

[14] Natl Univ Hlth Syst, Ctr Hlth Longev, Singapore, Singapore

[15] Washington Univ, Dept Neurol, St Louis, MO USA

[16] Univ Sydney, Sch Psychol, Sydney, NSW, Australia

[17] Ist Ricovero & Cura Carattere Sci Osped Policlin, UO Clin Neurol, Genoa, Italy

[18] Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet & Child &, Genoa, Italy

[19] Univ Florida, Inst Aging, Dept Aging & Geriatr Res, Coll Med, Gainesville, FL USA

[20] Univ Newcastle, Fac Hlth & Med, Sch Med & Publ Hlth, Newcastle, NSW, Australia

[21] Newcastle Univ, Populat Hlth Sci Inst, Newcastle Upon Tyne, Tyne & Wear, England

[22] Bezmialem Vakif Univ, Fac Med, Dept Geriatr Med, Istanbul, Turkiye

[23] European Soc Geriatr Med, Dementia Special Interest Grp, London, England

[24] Katholieke Univ Leuven, Leuven Brain Inst, Dept Neurosci, Neuropsychiat, Leuven, Belgium

[25] Katholieke Univ Leuven, Geriatr Psychiat, Univ Psychiat Ctr, Leuven, Belgium

[26] Alzheimers Assoc, Chicago, IL USA

[27] Maastricht Univ, Sch Mental Hlth & Neurosci MHeNS, Dept Psychiat & Neuropsychol, Maastricht, Netherlands

[28] Univ Amsterdam, Alzheimer Ctr, VU Med Ctr, Dept Neurol,Med Ctr, Neurosci Campus Amsterdam, Amsterdam, Netherlands

[29] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden

[30] San Francisco VA Med Ctr, San Francisco, CA USA

[31] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA USA

[32] Univ Geneva, Lab Neuroimaging Aging LANVIE, Geneva, Switzerland

[33] Univ Geneva, Dept Readaptat & Geriatr, Memory Clin, Geneva, Switzerland

[34] Univ Hosp, Geneva, Switzerland

来源：

ALZHEIMERS & DEMENTIA | 2023年

关键词：

Alzheimer's disease; consensus; Delphi; dementia; measures; outcomes; MILD COGNITIVE IMPAIRMENT; QUALITY-OF-LIFE; FUNCTIONAL-ACTIVITIES QUESTIONNAIRE; DAILY LIVING SCALE; REVISED ACE-R; INSTRUMENTAL-ACTIVITIES; NEUROPSYCHIATRIC INVENTORY; DEPRESSION SCALE; OLDER-ADULTS; CORNELL SCALE;

D O I：

10.1002/alz.12945

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

IntroductionWe aim to provide guidance on outcomes and measures for use in patients with Alzheimer's clinical syndrome. MethodsA consensus group of 20 voting members nominated by 10 professional societies, and a non-voting chair, used a Delphi approach and modified GRADE criteria. ResultsConsensus was reached on priority outcomes (n = 66), measures (n = 49) and statements (n = 37) across nine domains. A number of outcomes and measurement instruments were ranked for: Cognitive abilities; Functional abilities/dependency; Behavioural and neuropsychiatric symptoms; Patient quality of life (QoL); Caregiver QoL; Healthcare and treatment-related outcomes; Medical investigations; Disease-related life events; and Global outcomes. DiscussionThis work provides indications on the domains and ideal pertinent measurement instruments that clinicians may wish to use to follow patients with cognitive impairment. More work is needed to develop instruments that are more feasible in the context of the constraints of clinical routine.

引用

页码：2707 / 2729

页数：23

共 127 条

[1] The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
Albert, Marilyn S.
DeKosky, Steven T.
Dickson, Dennis
Dubois, Bruno
Feldman, Howard H.
Fox, Nick C.
Gamst, Anthony
Holtzman, David M.
Jagust, William J.
Petersen, Ronald C.
Snyder, Peter J.
Carrillo, Maria C.
Thies, Bill
Phelps, Creighton H.
[J]. ALZHEIMERS & DEMENTIA, 2011, 7 (03) : 270 - 279
[2] CORNELL SCALE FOR DEPRESSION IN DEMENTIA
ALEXOPOULOS, GS
ABRAMS, RC
YOUNG, RC
SHAMOIAN, CA
[J]. BIOLOGICAL PSYCHIATRY, 1988, 23 (03) : 271 - 284
[3] Beyond the global score of the Zarit Burden Interview: useful dimensions for clinicians
Ankri, J
Andrieu, S
Beaufils, B
Grand, A
Henrard, JC
[J]. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 2005, 20 (03) : 254 - 260
[4] 2020 Alzheimer's disease facts and figures
不详
[J]. ALZHEIMERS & DEMENTIA, 2020, 16 (03) : 391 - 460
[5] [Anonymous], MED COND DEM 2016
[6] Arbuthnott K, 2000, J CLIN EXP NEUROPSYC, V22, P518, DOI 10.1076/1380-3395(200008)22:4
[7] 1-0
[8] FT518
[9] Mini-Mental State Examination (MMSE) for the early detection of dementia in people with mild cognitive impairment (MCI)
Arevalo-Rodriguez, Ingrid
Smailagic, Nadja
Roque-Figuls, Marta
Ciapponi, Agustin
Sanchez-Perez, Erick
Giannakou, Antri
Pedraza, Olga L.
Cosp, Xavier Bonfill
Cullum, Sarah
[J]. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2021, (07):
[10] Now is the Time to Improve Cognitive Screening and Assessment for Clinical and Research Advancement
Ashford, J. Wesson
Schmitt, Frederick A.
Bergeron, Michael F.
Bayley, Peter J.
Clifford, James O.
Xu, Qun
Liu, Xiaolei
Zhou, Xianbo
Kumar, Vinod
Buschke, Herman
Dean, Margaret
Finkel, Sanford I.
Hyer, Lee
Perry, George
[J]. JOURNAL OF ALZHEIMERS DISEASE, 2022, 87 (01) : 305 - 315

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