Use of Monoclonal Antibodies in Immunocompromised Patients Hospitalized with Severe COVID-19: A Retrospective Multicenter Cohort

被引：5

作者：

Calderon-Parra, Jorge ^{[1
,2
]}

Guisado-Vasco, Pablo ^{[3
]}

Montejano-Sanchez, Rocio ^{[4
]}

Estrada, Vicente ^{[5
]}

Cuevas-Tascon, Guillermo ^{[6
]}

Aguareles, Jose ^{[3
]}

Arribas, Jose ^{[4
,7
]}

Erro-Iribarren, Marta ^{[8
]}

Calvo-Salvador, Marina ^{[9
]}

Fernandez-Cruz, Ana ^{[1
,2
]}

Ramos-Martinez, Antonio ^{[1
,2
]}

Munez-Rubio, Elena ^{[1
,2
]}

机构：

[1] Univ Hosp Puerta Hierro, Internal Med Dept, Infect Dis Unit, Majadahonda 28222, Spain

[2] Res Inst Puerta Hierro Segovia Aranda IDIPHISA, Majadahonda 28222, Spain

[3] Univ Hosp Quironsalud Madrid, Infect Dis Dept, Madrid 28223, Spain

[4] Univ Hosp La Paz, Infect Dis Unit, Madrid 28046, Spain

[5] Univ Hosp Clin San Carlos, Infect Dis Dept, Madrid 28040, Spain

[6] Univ Hosp Infanta Leonor, Internal Med Dept, Madrid 28031, Spain

[7] Ctr Invest Biomed Red Enfermedades Infecciosas CIB, Madrid 28029, Spain

[8] Univ Hosp Puerta Hierro, Pneumol Dept, Majadahonda 28222, Spain

[9] Univ Hosp Puerta Hierro, Pharmacol Dept, Majadahonda 28222, Spain

来源：

JOURNAL OF CLINICAL MEDICINE | 2023年 / 12卷 / 03期

关键词：

COVID-19; monoclonal antibodies; sotrovimab; severe COVID-19; immunocompromised hosts;

D O I：

10.3390/jcm12030864

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: We aim to describe the safety and efficacy of sotrovimab in severe cases of COVID-19 in immunocompromised hosts. Methods: We used a retrospective multicenter cohort including immunocompromised hospitalized patients with severe COVID-19 treated with sotrovimab between October 2021 and December 2021. Results: We included 32 patients. The main immunocompromising conditions were solid organ transplantation (46.9%) and hematological malignancy (37.5%). Seven patients (21.9%) had respiratory progression: 12.5% died and 9.4% required mechanical ventilation. Patients treated within the first 14 days of their symptoms had a lower progression rate: 12.0% vs. 57.1%, p = 0.029. No adverse event was attributed to sotrovimab. Conclusions: Sotrovimab was safe and may be effective in its use for immunocompromised patients with severe COVID-19. More studies are needed to confirm these preliminary data.

引用

页数：9

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