Rare myxoid pleomorphic liposarcoma: a case report and literature review

被引：2

作者：

Shen, Yanying ^{[1
]}

Zhao, Ling ^{[1
]}

Li, Anqi ^{[2
]}

Peng, Qi ^{[1
]}

Liu, Qiang ^{[1
]}

Wang, Lisha ^{[3
]}

Liu, Zebing ^{[4
]}

机构：

[1] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Pathol, Shanghai, Peoples R China

[2] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Pathol, Shanghai, Peoples R China

[3] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA USA

[4] Shanghai Jiao Tong Univ, Sch Med, Dept Pathol, Shanghai, Peoples R China

来源：

JOURNAL OF CLINICAL PATHOLOGY | 2024年 / 77卷 / 05期

关键词：

Sarcoma; Soft Tissue Neoplasms; Genes; Neoplasm;

D O I：

10.1136/jcp-2023-209223

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

We report a case of a middle-aged woman with a rapidly growing abdominal mass that was diagnosed as myxoid pleomorphic liposarcoma, a recently recognised, rare and aggressive subtype of liposarcoma. The tumour exhibits a combination of histological features from both myxoid liposarcoma and pleomorphic liposarcoma. Genetic analysis revealed mutations in TP53 and RB1, along with widespread loss of heterozygosity. However, no DDIT3 gene translocation or MDM2/CDK4 gene amplification was detected. These genetic characteristics can be used to distinguish this type of liposarcoma from others. Two unusual gene fusion/rearrangements, CREB5::TERT fusion and ETV1::LFNG rearrangement, were identified. The patient underwent complete removal of the tumour without the use of radiotherapy or chemotherapy. No recurrence was observed during the follow-up period of 18 months.

引用

页码：358 / 362

页数：5

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