Alterations of dynamic and static brain functional activities and integration in stroke patients

被引：2

作者：

Guo, Li ^{[1
,2
]}

Zhao, Zixuan ^{[1
,2
]}

Yang, Xu ^{[2
]}

Shi, Weiyang ^{[3
]}

Wang, Peng ^{[4
]}

Qin, Dongdong ^{[5
]}

Wang, Jiaojian ^{[6
]}

Yin, Yong ^{[2
]}

机构：

[1] Kunming Med Univ, Grad Sch, Kunming, Peoples R China

[2] Yunnan Univ, Affiliated Hosp, Dept Rehabil Med, Kunming, Peoples R China

[3] Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China

[4] Yunnan Univ, Dept Radiol, Affiliated Hosp, Kunming, Yunnan, Peoples R China

[5] Yunnan Univ Chinese Med, Key Lab Tradit Chinese Med Prevent & Treatment Neu, Kunming, Peoples R China

[6] Kunming Univ Sci & Technol, Inst Primate Translat Med, Yunnan Key Lab Primate Biomed Res, Kunming, Peoples R China

来源：

FRONTIERS IN NEUROSCIENCE | 2023年 / 17卷

基金：

中国国家自然科学基金;

关键词：

stroke; dynamic amplitude of low-frequency fluctuation; static amplitude of low-frequency fluctuation; dynamic degree centrality; static degree centrality; CONNECTIVITY; NETWORKS;

D O I：

10.3389/fnins.2023.1228645

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

ObjectiveThe study aimed to investigate the comprehensive characteristics of brain functional activity and integration in patients with subcortical stroke using dynamic and static analysis methods and to examine whether alterations in brain functional activity and integration were associated with clinical symptoms of patients.MethodsDynamic amplitude of low-frequency fluctuation (dALFF), static amplitude of low-frequency fluctuation (sALFF), dynamic degree centrality (dDC), and static degree centrality (sDC) were calculated for 19 patients with right subcortical stroke, 16 patients with left subcortical stroke, and 25 healthy controls (HC). Furthermore, correlation analysis was performed to investigate the relationships between changes in brain functional measurements of patients and clinical variables.ResultsGroup comparison results showed that significantly decreased dALFF in the left angular (ANG_L) and right inferior parietal gyrus (IPG_R), decreased sALFF in the left precuneus (PCUN_L), and decreased sDC in the left crus II of cerebellar hemisphere (CERCRU2_L) and IPG_R, while significantly increased sDC in the right lobule X of cerebellar hemisphere (CER10_R) were detected in patients with right subcortical stroke relative to HC. Patients with left subcortical stroke showed significantly decreased sALFF in the left precuneus (PCUN_L) but increased sDC in the right hippocampus (HIP_R) compared with HC. Additionally, the altered sDC values in the CER10_R of patients with right subcortical stroke and in the HIP_R of patients with left subcortical stroke were associated with the severity of stroke and lower extremities motor function. A correlation was also found between the altered sALFF values in the PCUN_L of patients with left subcortical stroke and lower extremities motor function.ConclusionThese findings suggest that time-varying brain activity analysis may supply complementary information for static brain activity analysis. Dynamic and static brain functional activity and integration analysis may contribute to a more comprehensive understanding of the underlying neuropathology of dysfunction in stroke patients.

引用

页数：9

共 51 条

[11] Individual-level brain morphological similarity networks: Current methodologies and applications [J].