Identification of 18F-FDG PET/CT Parameters Associated with Weight Loss in Patients with Esophageal Cancer

被引：4

作者：

Galvez, Thierry ^{[1
,2
]}

Berkane, Ikrame ^{[1
]}

Thezenas, Simon ^{[3
]}

Eberle, Marie-Claude ^{[1
]}

Flori, Nicolas ^{[4
,5
]}

Guillemard, Sophie ^{[1
]}

Ilonca, Alina Diana ^{[1
]}

Santoro, Lore ^{[1
]}

Kotzki, Pierre-Olivier ^{[1
,5
]}

Senesse, Pierre ^{[4
,5
]}

Deshayes, Emmanuel ^{[1
,5
]}

机构：

[1] Univ Montpellier, Inst Canc Montpellier, Dept Nucl Med, F-34298 Montpellier 5, France

[2] Univ Montpellier, CHU Montpellier, Dept Endocrinol Diabet & Nutr, F-34295 Montpellier, France

[3] Univ Montpellier, Inst Canc Montpellier, Biometry Unit, F-34298 Montpellier 5, France

[4] Univ Montpellier, Inst Canc Montpellier, Dept Clin Nutr & Gastroenterol, F-34298 Montpellier 5, France

[5] Univ Montpellier, Inst Rech Cancerol Montpellier IRCM, INSERM U1194, F-34298 Montpellier, France

来源：

NUTRIENTS | 2023年 / 15卷 / 13期

关键词：

malnutrition; F-18-FDG PET; CT; weight loss; brain metabolism; esophageal cancer; BRAIN GLUCOSE-METABOLISM; STANDARDIZED UPTAKE VALUE; NUTRITIONAL-STATUS; FDG; QUANTIFICATION; CACHEXIA; GUIDELINES; STARVATION; SURVIVAL; CRITERIA;

D O I：

10.3390/nu15133042

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

F-18-FDG PET-CT is routinely performed as part of the initial staging of numerous cancers. Other than having descriptive, predictive and prognostic values for tumors, F-18-FDG PET-CT provides full-body data, which could inform on concurrent pathophysiological processes such as malnutrition. To test this hypothesis, we measured the F-18-FDG uptake in several organs and evaluated their association with weight loss in patients at diagnosis of esophageal cancer. Forty-eight patients were included in this retrospective monocentric study. F-18-FDG uptake quantification was performed in the brain, the liver, the spleen, bone marrow, muscle and the esophageal tumor itself and was compared between patients with different amounts of weight loss. We found that Total Lesion Glycolysis (TLG) and peak Standardized Uptake Values (SUVpeak) measured in the brain correlated with the amount of weight loss: TLG was, on average, higher in patients who had lost more than 5% of their usual weight, whereas brain SUVpeak were, on average, lower in patients who had lost more than 10% of their weight. Higher TLG and lower brain SUVpeak were associated with worse OS in the univariate analysis. This study reports a new and significant association between F-18-FDG uptake in the brain and initial weight loss in patients with esophageal cancer.

引用

页数：12

共 46 条

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