Expression of PD-1/PD-L1 Axis and CD4/CD8 Ratio in Mediastinal Lymph Nodes of Human and Experimental Lung Fibrosis Indicates a Potential Therapeutic Target for Idiopathic Pulmonary Fibrosis

被引:0
作者
Karampitsakos, T. [1 ]
Galaris, A. [2 ]
Chrysikos, S. [3 ]
Papaioannou, O. [1 ]
Vamvakaris, I. [4 ]
Barbayianni, I. [2 ]
Kanellopoulou, P. [2 ]
Anagnostopoulos, A.
Stratakos, G.
Katsaras, M. [1 ]
Sampsonas, F. [1 ]
Dimakou, K.
Manali, E. [6 ]
Papiris, S. A. [6 ]
Bouros, D. [5 ]
Bakakos, P. [5 ]
Aidinis, V. [2 ]
Tzouvelekis, A. [1 ]
机构
[1] Univ Hosp Patras, Dept Resp Med, Patras, Greece
[2] Inst Bio Innovat, Biomed Sci Res Ctr Alexander Fleming, Athens, Greece
[3] SOTIRIA, Hosp Thorac Dis, Dept Pneumonol 5, Athens, Greece
[4] SOTIRIA, Hosp Thorac Dis, Dept Pathol, Athens, Greece
[5] Natl & Kapodistrian Univ Athens, Acad 1, Sch Med, Hosp Thorac Dis,Dept Pneumonol, Athens, Greece
[6] Natl & Kapodistrian Univ Athens, ATTIKON Univ Hosp, Athens Med Sch, Pulm Med Dept 2, Athens, Greece
关键词
D O I
暂无
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
A3956
引用
收藏
页数:1
相关论文
共 50 条
[31]   Programmed cell death 1 (PD-1) regulates the effector function of CD8 T cells via PD-L1 expressed on target keratinocytes [J].
Okiyama, Naoko ;
Katz, Stephen I. .
JOURNAL OF AUTOIMMUNITY, 2014, 53 :1-9
[32]   Appraisal of clinicopathological prognosticators in advanced acral lentiginous melanoma with characterization of PD-L1 and CD8/CD4 immunoprofiles [J].
Chuang, I-Chieh ;
Jang, Chiau-Sheng .
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2022, 52 (09) :975-981
[34]   PD-1 and its ligand PD-L1 are progressively up-regulated on CD4 and CD8 T-cells in HIV-2 infection irrespective of the presence of viremia [J].
Tendeiro, Rita ;
Foxall, Russell B. ;
Baptista, Antonio P. ;
Pinto, Francisco ;
Soares, Rui S. ;
Cavaleiro, Rita ;
Valadas, Emilia ;
Gomes, Perpetua ;
Victorino, Rui M. M. ;
Sousa, Ana E. .
AIDS, 2012, 26 (09) :1065-1071
[35]   High expression ITGA2 affects the expression of MET, PD-L1, CD4 and CD8 with the immune microenvironment in pancreatic cancer patients [J].
Jin, Liquan ;
Duan, Yaoqiang ;
Li, Xiaoxi ;
Li, Zhenqi ;
Hu, Jifu ;
Shi, Hongbo ;
Su, Ziting ;
Li, Zhe ;
Du, Bilian ;
Chen, Yiming ;
Tan, Yunbo .
FRONTIERS IN IMMUNOLOGY, 2023, 14
[37]   Clinical impact of programmed cell death ligand 1 (PD-L1), programmed cell death 1 (PD-1), and CD8 expression in pancreatic cancer [J].
Shim, Hyun-Jeong ;
Hwang, Jun-Eul ;
Jung, Sook-In ;
Lee, Kyung-Hwa ;
Chung, Ik-Joo ;
Cho, Sang-Hee .
JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)
[38]   CD4 T Cell Depletion Substantially Augments the Rescue Potential of PD-L1 Blockade for Deeply Exhausted CD8 T Cells [J].
Penaloza-MacMaster, Pablo ;
Provine, Nicholas M. ;
Blass, Eryn ;
Barouch, Dan H. .
JOURNAL OF IMMUNOLOGY, 2015, 195 (03) :1054-1063
[39]   Multiplex immunohistochemical staining of PD-L1, PD-1, CD3, CD4, CD8, CD68, FoxP3, and Ki-67 and image analysis of tumor and invasive margin in human FFPE NSCLC tissue [J].
Dauffenbach, Lisa M. ;
Sia, Gela C. ;
Zheng, Jianping ;
Jun, Natalia ;
Olsen, Eric P. ;
Kerfoot, Christopher A. .
CANCER RESEARCH, 2017, 77
[40]   The primordial differentiation of tumor specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes [J].
Huang, Qizhao ;
Wu, Xia ;
Wang, Zhiming ;
Chen, Xiangyu ;
Sun, Beicheng ;
Xu, Lifan ;
Tang, Zhonghui ;
Ye, Lilin .
CHINESE SCIENCE BULLETIN-CHINESE, 2022, 67 (35) :4152-4154