Oxidative Stress, Antioxidants and Hypertension

被引：71

作者：

Amponsah-Offeh, Michael ^{[1
,2
]}

Diaba-Nuhoho, Patrick ^{[3
,4
,5
]}

Speier, Stephan ^{[1
,6
,7
,8
]}

Morawietz, Henning ^{[3
,4
]}

机构：

[1] Tech Univ Dresden, Inst Physiol, Fac Med Carl Gustav Carus, Fetscherstr 74, D-01307 Dresden, Germany

[2] Heidelberg Univ, Med Fac Mannheim, European Ctr Angiosci ECAS, Dept Cardiovasc Res, D-68167 Mannheim, Germany

[3] Tech Univ Dresden, Univ Hosp, Dept Med 3, Div Vasc Endothelium & Microcirculat, D-01307 Dresden, Germany

[4] Tech Univ Dresden, Fac Med Carl Gustav Carus, D-01307 Dresden, Germany

[5] Univ Hosp Munster, Dept Paediat & Adolescent Med, Paediat Haematol & Oncol, D-48149 Munster, Germany

[6] Tech Univ Dresden, PLID, Helmholtz Zentrum Munchen, Univ Clin Carl Gustav Carus, Fetscherstr 74, D-01307 Dresden, Germany

[7] Tech Univ Dresden, Fac Med, Fetscherstr 74, D-01307 Dresden, Germany

[8] German Ctr Diabet Res DZD, D-85764 Munich, Germany

来源：

ANTIOXIDANTS | 2023年 / 12卷 / 02期

关键词：

hypertension; cardiovascular diseases; oxidative stress; reactive oxygen species; antioxidants; antihypertensive therapy; ALPHA-LIPOIC ACID; REDUCES BLOOD-PRESSURE; IMPROVES ENDOTHELIAL FUNCTION; SALT-INDUCED HYPERTENSION; DIETARY VITAMIN-E; SUPPLEMENTATION ATTENUATES HYPERTENSION; ROSTRAL VENTROLATERAL MEDULLA; FRUCTOSE-INDUCED HYPERTENSION; N-ACETYLCYSTEINE TREATMENT; RENIN-ANGIOTENSIN SYSTEM;

D O I：

10.3390/antiox12020281

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As a major cause of morbidity and mortality globally, hypertension remains a serious threat to global public health. Despite the availability of many antihypertensive medications, several hypertensive individuals are resistant to standard treatments, and are unable to control their blood pressure. Regulation of the renin-angiotensin-aldosterone system (RAAS) controlling blood pressure, activation of the immune system triggering inflammation and production of reactive oxygen species, leading to oxidative stress and redox-sensitive signaling, have been implicated in the pathogenesis of hypertension. Thus, besides standard antihypertensive medications, which lower arterial pressure, antioxidant medications were tested to improve antihypertensive treatment. We review and discuss the role of oxidative stress in the pathophysiology of hypertension and the potential use of antioxidants in the management of hypertension and its associated organ damage.

引用

页数：22

共 242 条

[1] NOX2-derived reactive oxygen species in immune cells exacerbates salt-sensitive hypertension [J].