Potential of Capric Acid in Neurological Disorders: An Overview

被引:12
作者
Shekhar, Nikhila [1 ]
Tyagi, Sakshi [1 ]
Rani, Sweta [2 ]
Thakur, Ajit Kumar [1 ]
机构
[1] Delhi Pharmaceut Sci & Res Univ, Sch Pharmaceut Sci, Neuropharmacol Res Lab, New Delhi 110017, India
[2] Delhi Pharmaceut Sci & Res Univ, Sch Allied Hlth Sci & Management, New Delhi 110017, India
关键词
Capric acid; Ketogenic diet; Neurological disorders; Metabolism; Neurotransmitter; CHAIN FATTY-ACIDS; GAMMA-AMINOBUTYRIC-ACID; LONG-TERM POTENTIATION; CENTRAL-NERVOUS-SYSTEM; KETOGENIC DIET; DECANOIC ACID; ALZHEIMER-DISEASE; MITOCHONDRIAL BIOGENESIS; GLUCOSE DEPRIVATION; RECEPTOR AGONISTS;
D O I
10.1007/s11064-022-03809-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
To solve the restrictions of a classical ketogenic diet, a modified medium-chain triglyceride diet was introduced which required only around 60% of dietary energy. Capric acid (CA), a small molecule, is one of the main components because its metabolic profile offers itself as an alternate source of energy to the brain in the form of ketone bodies. This is possible with the combined capability of CA to cross the blood-brain barrier and achieve a concentration of 50% concentration in the brain more than any other fatty acid in plasma. Natural sources of CA include vegetable oils such as palm oil and coconut oil, mammalian milk and some seeds. Several studies have shown that CA has varied action on targets that include AMPA receptors, PPAR-gamma, inflammatory/oxidative stress pathways and gut dysbiosis. Based on these lines of evidence, CA has proved to be effective in the amelioration of neurological diseases such as epilepsy, affective disorders and Alzheimer's disease. But these studies still warrant more pre-clinical and clinical studies that would further prove its efficacy. Hence, to understand the potential of CA in brain disease and associated comorbid conditions, an advance and rigorous molecular mechanistic study, apart from the reported in-vitro/in-vivo studies, is urgently required for the development of this compound through clinical setups.
引用
收藏
页码:697 / 712
页数:16
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