Microvessel Density (MVD) in Patients with Osteosarcoma: A Systematic Review and Meta-Analysis

被引：5

作者：

Perivoliotis, Konstantinos ^{[1
]}

Ntellas, Panagiotis ^{[2
]}

Dadouli, Katerina ^{[3
]}

Samara, Athina A. ^{[1
,5
]}

Sotiriou, Sotirios ^{[4
]}

Ioannou, Maria ^{[2
]}

Tepetes, Konstantinos ^{[1
]}

机构：

[1] Univ Hosp Larissa, Dept Surg, Larisa, Greece

[2] Univ Hosp Larissa, Dept Pathol, Larisa, Greece

[3] Univ Thessaly, Postgrad Programme, Res Methodol Biomed Biostat & Clin Bioinformat, Thessaly, Greece

[4] Univ Hosp Larissa, Dept Embryol, Larisa, Greece

[5] Univ Hosp Larissa Viopolis, Dept Surg, Larisa 41110, Greece

来源：

CANCER INVESTIGATION | 2024年 / 42卷 / 01期

关键词：

Microvessel; density; osteosarcoma; angiogenesis; meta-analysis; GROWTH-FACTOR EXPRESSION; TUMOR ANGIOGENESIS; PROGNOSTIC-FACTORS; SURVIVAL; METASTASIS; EPIDEMIOLOGY; THERAPY;

D O I：

10.1080/07357907.2024.2311266

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A meta-analysis was designed and conducted to estimate the effect of tumoral microvessel density (MVD) on the survival of patients with osteosarcoma. There was no difference between high and low MVD regarding the overall (OS) and disease-free (DFS) survival. Low MVD tumors displayed a lower DFS at the third year of follow-up. Although primary metastases did not affect the mean MVD measurements, tumors with a good chemotherapy response had a higher MVD value. Although no significant differences between tumoral MVD, OS and DFS were found, good adjuvant therapy responders had a significant higher vascularization pattern.

引用

页码：104 / 114

页数：11

共 58 条

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