Hip replacement surgery, though followed as an important treatment for femoral neck fractures, femoral head necrosis, osteoarthritis and rheumatoid arthritis, issues such as intraoperative mechanical ventilation and tracheal intubation for some critically ill patients, particularly the elderly, pose a great challenge to general anesthesia surgery. Not only it makes the surgery more difficult, but also affects the quality of life during the recovery period and relevant vital signs of patients. Ultrasound-guided fascia iliaca compartment block (FICB), as a postoperative analgesia mode in clinical practice, effectively relieves postoperative pain and also reduces cardiovascular adverse events and over-analgesia complications. Here, we explored the effects of FICB combined with general anesthesia under tracheal intubation on the vital signs and quality of recovery of elderly patients receiving hip replacement. A total of 75 elderly patients undergoing hip replacement were randomly divided into an observation group and a control group. All patients underwent general anesthesia under tracheal intubation and were given routine postoperative patient-controlled intravenous analgesia. One minute before skin cutting, at the time of incision suture and at 30 min after entering the anesthesia recovery room, blood oxygen saturation was higher in the observation group than that in the control group, while heart rate and mean arterial pressure were significantly lower in the observation group (P <0.05). The observation group had lower Visual Analogue Scale scores than the control group 2 h, 12 h, 24h and 48 h after recovery, and higher Ramsay sedation score 30 min, 2 h and 12 h after recovery (P <0.05). Ultrasound-guided FICB combined with general anesthesia under tracheal intubation can significantly ameliorate the vital signs and quality of recovery of elderly patients receiving hip replacement.