Recurrent Papillary Bladder Tumors in a Boy With Lynch Syndrome

被引：1

作者：

Tua-Caraccia, Rafael ^{[1
,2
]}

Livingston, Austin ^{[1
]}

Routh, Jonathan C. ^{[1
]}

机构：

[1] Duke Univ, Sch Med, Dept Urol, Durham, NC USA

[2] DUMC Box 3831, Durham, NC 27710 USA

来源：

UROLOGY | 2023年 / 181卷

关键词：

CARCINOMA; CANCER; RISK;

D O I：

10.1016/j.urology.2023.06.016

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Lynch syndrome (LS) is an autosomal dominant genetic disorder defined by germline mutations in one of four mismatch repair genes including PMS2, MLH2, MSH1, MSH2, or deletion in the EPCAM gene.(1) The most common urologic manifestation of LS is upper tract urothelial carcinoma, which occurs in up to 20% of patients with LS.(2) While data are scarce, there is growing evidence of an increased relative risk of bladder malignancy in patients with LS.(3,4) Bladder tumors in children are a rare entity and the link between pediatric bladder tumors and LS has not been previously reported to our knowledge. UROLOGY 181: 133-135, 2023. (c) 2023 Elsevier Inc. All rights reserved.

引用

页码：133 / 135

页数：3

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