Readjustment of nodal staging by integrating tumor deposits and positive lymph nodes in patients with stage III colon cancer: a population-based analysis

被引:0
|
作者
Lin, Yi-Hong [1 ,2 ]
Chen, Qun-Xiang [3 ]
Lu, Lin -Bin [3 ]
Chen, Hong [3 ]
Wu, Jun-Xian [3 ]
Wang, Xue-Wen [3 ]
Chen, Ya-Ying [3 ]
Lin, Qin [3 ]
Li, Jie [3 ]
Chen, Xi [3 ]
机构
[1] Fujian Med Univ, Fuzhou, Fujian, Peoples R China
[2] Fudan Univ, Shanghai Canc Ctr Xiamen, Dept Oncol, Xiamen, Fujian, Peoples R China
[3] Fujian Med Univ, Hosp Peoples Liberat Army Joint Serv Support Force, Dept Oncol, Fuzong Clin Med Coll, Fuzhou, Fujian, Peoples R China
来源
AMERICAN JOURNAL OF CANCER RESEARCH | 2023年 / 13卷 / 10期
关键词
Stage III colon cancer; tumor deposits; lymph node metastasis; new pN staging system; survival; COLORECTAL LIVER METASTASES; PROGNOSTIC IMPACT; RESECTION; SURVIVAL;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Whether tumor deposits (TDs) should be classified as lymph node metastasis or distant metastasis remains controversial. To address this predicament, we conducted this study to identify the predictive value of TDs on the survival of patients diagnosed with stage III colon cancer (CC). 12,904 eligible patients diagnosed with stage III CC between 2010 and 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. The best cutoff point of TD quantity was determined based on the difference in survival. Cox proportional hazards model was employed to perform univariate and multivariate analyses. The Kaplan-Meier method and log-rank test were performed to calculate the differences between overall survival (OS). Our results showed that the number of TDs was a significant prognostic factor in patients with stage III CC (P < 0.0001). We added the number of TDs to the pN stage and devised a new pN stage, there were no significant differences in the survival of npN, except npN2a (P > 0.05). Upon re-staging to the same npN stage, the difference in survival between TDs+ and TDs- disappeared (P > 0.05). The median survival times for N2aTDs > 4 and N2bTDs > 4 were 33 and 37 months, respectively, which were significantly shorter than that of N2TDs- (65 months) and represented the worst survival rates among all groups. In conclusion, the number of TDs indicated a poor prognosis for patients with stage III CC. Incorporating TDs into the pN is feasible to predict prognosis.
引用
收藏
页码:4976 / 4988
页数:13
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