Investigation of androgen receptor CAG repeats length in polycystic ovary syndrome diagnosed using the new international evidence-based guideline

被引：1
作者：
Yan, Xueqi [1 ,2 ,3 ,4 ,5 ,6 ,7 ]
Gao, Xueying [1 ,2 ,3 ,4 ,5 ,6 ,7 ,8 ,9 ]
Shang, Qian [1 ,2 ,3 ,4 ,5 ,6 ,7 ]
Yang, Ziyi [1 ,2 ,3 ,4 ,5 ,6 ,7 ]
Wang, Yuteng [1 ,2 ,3 ,4 ,5 ,6 ,7 ]
Liu, Li [10 ]
Liu, Wei [11 ]
Liu, Dan [12 ]
Cheng, Fang [10 ]
Zhao, Shigang [1 ,2 ,3 ,4 ,5 ,6 ,7 ]
Zhao, Han [1 ,2 ,3 ,4 ,5 ,6 ,7 ]
Zhao, Junli [13 ,14 ]
Chen, Zi-Jiang [1 ,2 ,3 ,4 ,5 ,6 ,7 ,8 ,9 ]
机构：
[1] Shandong Univ, Ctr Reprod Med, Jinan 250012, Shandong, Peoples R China
[2] State Key Lab Reprod Med & Offspring Hlth, Jinan 250012, Shandong, Peoples R China
[3] Shandong Univ, Key Lab Reprod Endocrinol, Minist Educ, Jinan 250012, Shandong, Peoples R China
[4] Shandong Key Lab Reprod Med, Jinan 250012, Shandong, Peoples R China
[5] Shandong Prov Clin Res Ctr Reprod Hlth, Jinan 250012, Shandong, Peoples R China
[6] Shandong Technol Innovat Ctr Reprod Hlth, Jinan 250012, Shandong, Peoples R China
[7] Shandong Univ, Natl Res Ctr Assisted Reprod Technol & Reprod Gene, Jinan 250012, Shandong, Peoples R China
[8] Shanghai Jiao Tong Univ, Ren Ji Hosp, Ctr Reprod Med, Sch Med, Shanghai, Peoples R China
[9] Shanghai Key Lab Assisted Reprod & Reprod Genet, Shanghai, Peoples R China
[10] Yinchuan Maternal & Child Hlth Hosp, Yinchuan 750001, Ningxia, Peoples R China
[11] Northwest Womens & Childrens Hosp, Xian 710100, Shanxi, Peoples R China
[12] Air Force Mil Med Univ, Tang Du Hosp, Reprod Med Ctr, Dept Obstet & Gynaecol, Xian 710038, Shanxi, Peoples R China
[13] Ningxia Med Univ, Gen Hosp, Yinchuan, Ningxia, Peoples R China
[14] Ningxia Med Univ, Gen Hosp, Dept Reprod Med, Yinchuan, Ningxia, Peoples R China
来源：
JOURNAL OF OVARIAN RESEARCH | 2023年 / 16卷 / 01期
关键词：
Polycystic ovary syndrome; Polycystic ovarian morphology; Androgen receptor; CAG repeats; Genetic polymorphism; TRINUCLEOTIDE REPEATS; POLYMORPHISM; WOMEN; INACTIVATION; INFERTILITY;
D O I：
10.1186/s13048-023-01295-y
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Background To study whether CAG repeat polymorphism of androgen receptor (AR) contributes to the risk of polycystic ovarian morphology (PCOM) with antral follicle count (AFC) >= 20 in the context of new international guideline of polycystic ovary syndrome (PCOS).Methods Blood of 109 PCOS cases and 61 controls were collected for the measurement of AR CAG repeats length by sequencing. The mean number and frequency distribution of CAG repeats length were observed. Detailed analysis was conducted by dividing PCOS cases into low AFC group (L-AFC, AFC < 20) and high AFC group (H-AFC, AFC >= 20) according to the new international evidence-based guideline.Results The portion of individuals with lower CAG repeats length in H-AFC group was significantly larger than those with higher CAG repeats length. Logistic model revealed individuals with lower CAG length tended to develop H-AFC.Conclusion Lower CAG repeats length in the AR gene of PCOS cases increases risk of PCOM.
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页数：7
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