Predictive value of co-expression patterns of immune checkpoint molecules for clinical outcomes of hematological malignancies

被引：8

作者：

Chen, Cunte ^{[1
]}

Li, Yangqiu ^{[2
]}

机构：

[1] South China Univ Technol, Guangzhou Peoples Hosp 1, Sch Med, Dept Hematol, Guangzhou 510180, Peoples R China

[2] Jinan Univ, Inst Hematol, Sch Med, Key Lab Regenerat Med,Minist Educ, Guangzhou 510632, Peoples R China

来源：

CHINESE JOURNAL OF CANCER RESEARCH | 2023年 / 35卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Immune checkpoint; T cell exhaustion; co-expression pattern; prognosis; hematological malignancy; PD-1; EXPRESSION; PHASE-II; BLOCKADE; NIVOLUMAB;

D O I：

10.21147/j.issn.1000-9604.2023.03.04

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Co-expression of immune checkpoint (IC) molecules can exacerbate T cell exhaustion in patients with hematological malignancies (HMs) and contribute to the immune escape of tumor cells, which is related to poor clinical outcome. It is worth establishing and optimizing an ideal prediction model based on the co-expression patterns of IC molecules to evaluate the immune status of HM patients and predict their clinical outcome. In this perspective, we summarize the co-expression patterns of IC molecules and their importance as biomarkers that predict the prognosis of patients with different HMs, providing new insights for designing dual IC blockades (ICBs).

引用

页码：245 / 251

页数：8

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