Targeting Cellular Senescence in Aging and Age-Related Diseases: Challenges, Considerations, and the Emerging Role of Senolytic and Senomorphic Therapies

被引：15
作者：
Zheng, Liyao [1 ,2 ,3 ,4 ]
He, Shipei [1 ,2 ,3 ,4 ]
Wang, Hong [1 ,2 ,3 ,4 ]
Li, Jinling [1 ,2 ,3 ,4 ]
Liu, Yuanyuan [1 ,2 ]
Liu, Sijia [1 ,2 ,3 ,4 ]
机构：
[1] Guangxi Med Univ, Collaborat Innovat Ctr Regenerat Med & Med BioRes, Guangxi Key Lab Regenerat Med, Nanning, Guangxi, Peoples R China
[2] Guangxi Med Univ, Key Lab Longev & Aging Related Dis Chinese Minist, Nanning, Guangxi, Peoples R China
[3] Guangxi Med Univ, Sch Basic Med Sci, Guangxi Coll & Univ Key Lab Biol Mol Med Res, Nanning, Guangxi, Peoples R China
[4] Guangxi Med Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Guangxi Key Lab Brain Sci, Nanning, Guangxi, Peoples R China
来源：
AGING AND DISEASE | 2024年 / 15卷 / 06期
关键词：
aging; age-related diseases; senolytics; senomorphics; senescent cells; HIGH-FAT DIET; LIFE-SPAN; MOLECULAR-MECHANISMS; PARKINSONS-DISEASE; GENE-THERAPY; SACCHAROMYCES-CEREVISIAE; NICOTINAMIDE RIBOSIDE; PREMATURE SENESCENCE; SECRETORY PHENOTYPE; ALZHEIMERS-DISEASE;
D O I：
10.14336/AD.2024.0206
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Cellular senescence is characterized by the permanent arrest of cell proliferation and is a response to endogenous and exogenous stress. The continuous accumulation of senescent cells (SnCs) in the body leads to the development of aging and age-related diseases (such as neurodegenerative diseases, cancer, metabolic diseases, cardiovascular diseases, and osteoarthritis). In the face of the growing challenge of aging and age-related diseases, several compounds have received widespread attention for their potential to target SnCs. As a result, senolytics (compounds that selectively eliminate SnCs) and senomorphics (compounds that alter intercellular communication and modulate the behavior of SnCs) have become hot research topics in the field of anti-aging. In addition, strategies such as combination therapies and immune-based approaches have also made significant progress in the field of anti- aging therapy. In this article, we discuss the latest research on anti-aging targeting SnCs and gain a deeper understanding of the mechanism of action and impact of different anti-aging strategies on aging and age-related diseases, with the aim of providing more effective references and therapeutic ideas for clinical anti-aging treatment in the face of the ever-grave challenges of aging and age-related diseases.
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收藏
页码：2554 / 2594
页数：41
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