A Highly Selective Implantable Electrochemical Fiber Sensor for Real-Time Monitoring of Blood Homovanillic Acid

被引：17

作者：

Zou, Kuangyi ^{[1
]}

Li, Qianming ^{[1
]}

Li, Dan ^{[2
]}

Jiao, Yiding ^{[1
]}

Wang, Lie ^{[1
]}

Li, Luhe ^{[1
]}

Wang, Jiacheng ^{[1
]}

Li, Yiran ^{[1
]}

Gao, Rui ^{[1
]}

Li, Fangyan ^{[1
]}

He, Er ^{[1
]}

Ye, Tingting ^{[1
]}

Tang, Wentao ^{[2
]}

Song, Jie ^{[1
]}

Lu, Jiang ^{[1
]}

Li, Xusong ^{[1
]}

Zhang, Hanting ^{[1
]}

Cao, Xinyin ^{[1
]}

Zhang, Ye ^{[1
]}

机构：

[1] Nanjing Univ, Coll Engn & Appl Sci, Chem & Biomed Innovat Ctr, Collaborat Innovat Ctr Adv Microstruct,Natl Lab So, Nanjing 210023, Peoples R China

[2] Nanjing Univ Chinese Med, Sch Med & Holist Integrat Med, Dept Immunol, Nanjing 210023, Peoples R China

来源：

ACS NANO | 2024年 / 18卷 / 10期

基金：

中国国家自然科学基金;

关键词：

high selectivity; implantable fiber sensor; real-time monitoring; molecularly imprinted polymer; homovanillic acid; BRAIN; SCHIZOPHRENIA; METABOLITES; DOPAMINE;

D O I：

10.1021/acsnano.3c11641

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Homovanillic acid (HVA) is a major dopamine metabolite, and blood HVA is considered as central nervous system (CNS) dopamine biomarker, which reflects the progression of dopamine-associated CNS diseases and the behavioral response to therapeutic drugs. However, facing blood various active substances interference, particularly structurally similar catecholamines and their metabolites, real-time and accurate monitoring of blood HVA remains a challenge. Herein, a highly selective implantable electrochemical fiber sensor based on a molecularly imprinted polymer is reported to accurately monitor HVA in vivo. The sensor exhibits high selectivity, with a response intensity to HVA 12.6 times greater than that of catecholamines and their metabolites, achieving 97.8% accuracy in vivo. The sensor injected into the rat caudal vein tracked the real-time changes of blood HVA, which paralleled the brain dopamine fluctuations and indicated the behavioral response to dopamine increase. This study provides a universal design strategy for improving the selectivity of implantable electrochemical sensors.

引用

页码：7485 / 7495

页数：11

共 41 条

[1] Investigation of uranium (VI) adsorption by polypyrrole [J].

Abdi, S. ;

Nasiri, M. ;

Mesbahi, A. ;

Khani, M. H. .

JOURNAL OF HAZARDOUS MATERIALS, 2017, 332 :132-139

[2] Plasma homovanillic acid differences in clinical subgroups of first episode schizophrenic patients [J].

Baeza, Immaculada ;

Castro-Fornieles, Josefina ;

Deulofeu, Ramon ;

de la Serna, Elena ;

Goti, Javier ;

Salva, Joan ;

Bernardo, Miquel .

PSYCHIATRY RESEARCH, 2009, 168 (02) :110-118

[3] Late-onset Parkinsonism in NFκB/c-Rel-deficient mice [J].

Baiguera, Cristina ;

Alghisi, Manuela ;

Pinna, Annalisa ;

Bellucci, Arianna ;

De Luca, Maria Antonietta ;

Frau, Lucia ;

Morelli, Micaela ;

Ingrassia, Rosaria ;

Benarese, Marina ;

Porrini, Vanessa ;

Pellitteri, Michele ;

Bertini, Giuseppe ;

Fabene, Paolo Francesco ;

Sigala, Sandra ;

Spillantini, Maria Grazia ;

Liou, Hsiou-Chi ;

Spano, Pier Franco ;

Pizzi, Marina .

BRAIN, 2012, 135 :2750-2765

[4] Prognostic value of ferritin, neuron-specific enolase, lactate dehydrogenase, and urinary and plasmatic catecholamine metabolites in children with neuroblastoma [J].

Cangemi, Giuliana ;

Reggiardo, Giorgio ;

Barco, Sebastiano ;

Barbagallo, Laura ;

Conte, Massimo ;

D'Angelo, Paolo ;

Bianchi, Maurizio ;

Favre, Claudio ;

Galleni, Barbara ;

Melioli, Giovanni ;

Haupt, Riccardo ;

Garaventa, Alberto ;

Corrias, Maria V. .

ONCOTARGETS AND THERAPY, 2012, 5 :417-423

[5] Plasma homovanillic acid in adolescents with bulimia nervosa [J].

Castro-Fornieles, Josefina ;

Deulofeu, Ramon ;

Martinez-Mallen, Esteve ;

Baeza, Immaculada ;

Fernandez, Lorena ;

Lazaro, Luisa ;

Toro, Josep ;

Vila, Montserrat ;

Bernardo, Miquel .

PSYCHIATRY RESEARCH, 2009, 170 (2-3) :241-244

[6] In situ synthesis and dynamic simulation of molecularly imprinted polymeric nanoparticles on a micro-reactor system [J].

Erdem, Ozgecan ;

Es, Ismail ;

Saylan, Yeseren ;

Atabay, Maryam ;

Gungen, Murat Alp ;

Olmez, Kadriye ;

Denizli, Adil ;

Inci, Fatih .

NATURE COMMUNICATIONS, 2023, 14 (01)

[7] Multikinase Abl/DDR/Src Inhibition Produces Optimal Effects for Tyrosine Kinase Inhibition in Neurodegeneration [J].

Fowler, Alan J. ;

Hebron, Michaeline ;

Missner, Alexander A. ;

Wang, Ruchong ;

Gao, Xiaokong ;

Kurd-Misto, Bahjat T. ;

Liu, Xiaoguang ;

Moussa, Charbel E. -H. .

DRUGS IN R&D, 2019, 19 (02) :149-166

[8] STRUCTURE AND FUNCTION OF THE SKELETAL MUSCLE EXTRACELLULAR MATRIX [J].

Gillies, Allison R. ;

Lieber, Richard L. .

MUSCLE & NERVE, 2011, 44 (03) :318-331

[9] Sources and significance of plasma levels of catechols and their metabolites in humans [J].

Goldstein, DS ;

Eisenhofer, G ;

Kopin, IJ .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2003, 305 (03) :800-811

[10] On-Demand, Reversible, Ultrasensitive Polymer Membrane Based on Molecular Imprinting Polymer [J].

Hemed, Nofar Mintz ;

Leal-Ortiz, Sergio ;

Zhao, Eric T. ;

Melosh, Nicholas A. .

ACS NANO, 2023, 17 (06) :5632-5643

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