A Rare Case of Adrenocortical Carcinoma Manifesting as a Pulmonary Embolism

被引:0
作者
Durairaj, Madeline Vithya Barnaba [1 ]
Shallenburg, Kasey [1 ]
Ashri, Neeraj [2 ]
Rajput, Punam [2 ]
机构
[1] UNC Hlth Blue Ridge, Internal Med, Morganton, NC 28655 USA
[2] Atrium Hlth, Diabet & Endocrinol, Kings Mt, NC USA
关键词
Categories; Endocrinology/Diabetes/Metabolism; Pulmonology cushing's syndrome; hirsutism; virilization; pulmonary embolism (pe); adrenocortical carcinoma (acc); MANAGEMENT; DIAGNOSIS;
D O I
10.7759/cureus.52929
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Adrenocortical carcinoma (ACC) is a very rare malignancy with a poor prognosis. It is predominantly noted in the fourth to fifth decades of life and is more common in White females. ACC is most commonly detected as an incidental finding but may have other presentations, such as rapid -onset Cushing's syndrome or pulmonary embolism. In the current case, ACC was incidentally observed in a 24 -year -old female during imaging, and the patient later developed a pulmonary embolism. Lab investigations were suggestive of hypercortisolism along with hyperandrogenism. Following preoperative treatment with beta-blockers, metyrapone, and therapeutic anticoagulation, she underwent left radical nephrectomy with left open adrenalectomy and inferior vena cava (IVC) resection and reconstruction. Surgery was uncomplicated, and she was discharged with plans for outpatient adjuvant chemotherapy. This case highlights the fact that a seemingly unprovoked pulmonary embolism may point to the possibility of an underlying occult malignancy and undetected ACC should be included in the differential diagnosis of such cases.
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页数:7
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