Non-coding RNAs modulate pyroptosis in myocardial ischemia-reperfusion injury: A comprehensive review

被引：6

作者：

Sun, Yi ^{[1
,2
,3
]}

Chu, Shujuan ^{[1
,2
,3
]}

Wang, Rong ^{[1
,2
,3
]}

Xia, Rui ^{[1
,2
,3
]}

Sun, Meng ^{[1
,2
,3
]}

Gao, Zhixiong ^{[1
,2
,3
]}

Xia, Zhengyuan ^{[4
]}

Zhang, Yan ^{[1
,2
,3
]}

Dong, Siwei ^{[1
,2
,3
]}

Wang, Tingting ^{[1
,2
,3
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Anesthesiol, Wuhan, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Inst Anesthesia & Crit Care Med, Wuhan, Peoples R China

[3] Huazhong Univ Sci & Technol, Key Lab Anesthesiol & Resuscitat, Minist Educ, Wuhan, Peoples R China

[4] Guangdong Med Univ, Affiliated Hosp, Dept Anesthesiol, Zhanjiang, Guangdong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2024年 / 257卷

基金：

中国国家自然科学基金;

关键词：

Non-coding RNAs; Myocardial ischemia-reperfusion injury; Pyroptosis; ISCHEMIA/REPERFUSION INJURY; LNCRNA PVT1; CELL-DEATH; APOPTOSIS; INFLAMMASOME; CARDIOMYOCYTES; EXPRESSION; PATHWAY; DIFFERENTIATION; MICRORNA-148A;

D O I：

10.1016/j.ijbiomac.2023.128558

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reperfusion therapy is the most effective treatment for acute myocardial infarction. However, reperfusion itself can also cause cardiomyocytes damage. Pyroptosis has been shown to be an important mode of myocardial cell death during ischemia-reperfusion. Non-coding RNAs (ncRNAs) play critical roles in regulating pyroptosis. The regulation of pyroptosis by microRNAs, long ncRNAs, and circular RNAs may represent a new mechanism of myocardial ischemia-reperfusion injury. This review summarizes the currently known regulatory roles of ncRNAs in myocardial ischemia-reperfusion injury and interactions between ncRNAs. Potential therapeutic strategies using ncRNA modulation are also discussed.

引用

页数：10