COVID-19 vaccination acceptance, safety and side-effects in European patients with severe asthma

被引：4

作者：

Bossios, Apostolos ^{[1
,2
,3
]}

Bacon, Alison M. ^{[4
]}

Eger, Katrien ^{[5
]}

Paroczai, Dora ^{[6
,7
]}

Schleich, Florence ^{[8
]}

Hanon, Shane ^{[9
]}

Sergejeva, Svetlana ^{[10
]}

Zervas, Eleftherios ^{[11
]}

Katsoulis, Konstantinos ^{[12
]}

Aggelopoulou, Christina ^{[13
]}

Kostikas, Konstantinos ^{[13
]}

Gaki, Eleni ^{[13
]}

Rovina, Nikoletta ^{[14
]}

Csoma, Zsuzsanna ^{[15
]}

Grisle, Ineta ^{[16
]}

Bieksiene, Kristina ^{[17
]}

Palacionyte, Jolita ^{[17
]}

ten Brinke, Anneke ^{[18
]}

Hashimoto, Simone ^{[5
]}

Mihaltan, Florin ^{[19
]}

Nenasheva, Natalia ^{[20
]}

Zvezdin, Biljana ^{[21
]}

Cekerevac, Ivan ^{[22
,23
]}

Hromis, Sanja ^{[21
,24
]}

Cupurdija, Vojislav ^{[22
,23
]}

Lazic, Zorica ^{[22
,23
]}

Chaudhuri, Rekha ^{[25
]}

Smith, Steven James ^{[25
]}

Rupani, Hitasha ^{[26
]}

Haitchi, Hans Michael ^{[26
]}

Kurukulaaratchy, Ramesh ^{[26
]}

Fulton, Olivia ^{[27
]}

Frankemolle, Betty ^{[28
]}

Howarth, Peter ^{[29
]}

Porsbjerg, Celeste ^{[30
]}

Bel, Elisabeth H. ^{[5
]}

Djukanovic, Ratko ^{[26
]}

Hyland, Michael E. ^{[31
]}

机构：

[1] Karolinska Univ Hosp, Karolinska Severe Asthma Ctr, Dept Resp Med & Allergy, Huddinge, Sweden

[2] Karolinska Inst, Dept Med, Stockholm, Sweden

[3] Karolinska Inst, Inst Environm Med, Div Lung & Airway Res, Stockholm, Sweden

[4] Univ Plymouth, Sch Psychol, Plymouth, Devon, England

[5] Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands

[6] Univ Szeged, Csongrad Cty Hosp, Szeged, Hungary

[7] Univ Szeged, Dept Pulmonol, Szeged, Hungary

[8] CHU Liege, Liege, Belgium

[9] Vrije Univ Brussel VUB, Univ Ziekenhuis Brussel UZ Brussel, Div Resp, Brussels, Belgium

[10] North Estonian Med Ctr, Tallinn, Estonia

[11] Athens Chest Hosp, Resp Dept 7, Athens, Greece

[12] 424 Army Gen Hosp, Dept Pulm, Thessaloniki, Greece

[13] Univ Hosp Ioannina, Resp Med Dept, Ioannina, Greece

[14] Natl & Kapodistrian Univ Athens, Athens Med Sch, Sotiria Hosp, Dept Pulm Med 1, Athens, Greece

[15] Natl Koranyi Inst Pulmonol, Budapest, Hungary

[16] Riga East Univ Hosp, Riga, Latvia

[17] Univ Hlth Sci, Kaunas, Lithuania

[18] Med Ctr Leeuwarden, Leeuwarden, Netherlands

[19] Natl Inst Pneumol, Bucharest, Romania

[20] Russian Med Acad Continuous Profess Educ, Minist Healthcare, Moscow, Russia

[21] Inst Pulm Dis Vojvodina, Sremska Kamenica, Serbia

[22] Univ Clin Ctr Kragujevac, Clin Pulmonol, Kragujevac, Serbia

[23] Univ Kragujevac, Dept Internal Med, Fac Med Sci, Kragujevac, Serbia

[24] Univ Novi Sad, Fac Med, Novi Sad, Serbia

[25] Gartnavel Royal Hosp, Glasgow, Lanark, Scotland

[26] Southampton Univ Hosp, Southampton, Hants, England

[27] European Lung Fdn, Patient Advisory Grp, Edinburgh, Midlothian, Scotland

[28] European Lung Fdn, Patient Advisory Grp, Heemskerk, Netherlands

[29] GSK, Brentford, England

[30] Bispebjerg Hosp, Copenhagen, Denmark

[31] Plymouth Marjon Univ, Plymouth, Devon, England

来源：

ERJ OPEN RESEARCH | 2023年 / 9卷 / 06期

关键词：

HESITANCY; WILLINGNESS; VACCINES;

D O I：

10.1183/23120541.00590-2023

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background Vaccination is vital for achieving population immunity to severe acute respiratory syndrome coronavirus 2, but vaccination hesitancy presents a threat to achieving widespread immunity. Vaccine acceptance in chronic potentially immunosuppressed patients is largely unclear, especially in patients with asthma. The aim of this study was to investigate the vaccination experience in people with severe asthma. Methods Questionnaires about vaccination beliefs (including the Vaccination Attitudes Examination (VAX) scale, a measure of vaccination hesitancy-related beliefs), vaccination side-effects, asthma control and overall safety perceptions following coronavirus disease 2019 (COVID-19) vaccination were sent to patients with severe asthma in 12 European countries between May and June 2021. Results 660 participants returned completed questionnaires (87.4% response rate). Of these, 88% stated that they had been, or intended to be, vaccinated, 9.5% were undecided/hesitant and 3% had refused vaccination. Patients who hesitated or refused vaccination had more negative beliefs towards vaccination. Most patients reported mild (48.2%) or no side-effects (43.8%). Patients reporting severe side-effects (5.7%) had more negative beliefs. Most patients (88.8%) reported no change in asthma symptoms after vaccination, while 2.4% reported an improvement, 5.3% a slight deterioration and 1.2% a considerable deterioration. Almost all vaccinated (98%) patients would recommend vaccination to other severe asthma patients. Conclusions Uptake of vaccination in patients with severe asthma in Europe was high, with a small minority refusing vaccination. Beliefs predicted vaccination behaviour and side-effects. Vaccination had little impact on asthma control. Our findings in people with severe asthma support the broad message that COVID-19 vaccination is safe and well tolerated.

引用

页数：10

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