Long-Term Consequences of COVID-19 in Predominantly Immunonaive Patients: A Canadian Prospective Population-Based Study

被引:3
作者
Benoit-Piau, Justine [1 ]
Tremblay, Karine [2 ]
Piche, Alain [3 ]
Dallaire, Frederic [4 ]
Belanger, Mathieu [5 ]
d'Entremont, Marc-Andre [6 ,7 ]
Pasquier, Jean-Charles [8 ]
Fortin, Martin [5 ]
Bourque, Catherine [6 ]
Lapointe, Fanny [2 ]
Betala-Belinga, Jean-Francois [9 ]
Petit, Genevieve [10 ]
Jourdan, Guillaume [3 ]
Bahous, Renata [11 ]
Maya, Camilo [11 ]
Benzina, Amira [11 ]
Faiyaz Hossain, Muhammad [11 ]
Peel, Marie-Audrey [11 ]
Houle, Olivier [11 ]
Auger, Marie-Sandrine [11 ]
Rioux, Antoine [11 ]
Farand, Paul [6 ]
机构
[1] Univ Sherbrooke, Ctr Hosp Univ Sherbrooke CHUS, Res Ctr, Sherbrooke, PQ J1H 5N4, Canada
[2] Univ Sherbrooke, Fac Med & Hlth Sci, Pharmacol & Physiol Dept, Sherbrooke, PQ J1H 5N4, Canada
[3] Univ Sherbrooke, Dept Microbiol & Infectiol, Sherbrooke, PQ J1H 5N4, Canada
[4] Univ Sherbrooke, Dept Pediat, Sherbrooke, PQ J1H 5N4, Canada
[5] Univ Sherbrooke, Dept Family & Emergency Med, Sherbrooke, PQ J1H 5N4, Canada
[6] Univ Sherbrooke, Fac Med & Hlth Sci, Dept Med, Div Cardiol, Sherbrooke, PQ J1H 5N4, Canada
[7] Populat Hlth Res Inst, Hamilton, ON L8L 2X2, Canada
[8] Univ Sherbrooke, Dept Obstet & Gynecol, Sherbrooke, PQ J1H 5N4, Canada
[9] Direct Saguenay Lac St Jean Publ Hlth Dept, Saguenay, PQ J1H 5N4, Canada
[10] Univ Sherbrooke, Fac Med & Hlth Sci, Dept Community Hlth Sci, Sherbrooke, PQ J1H 5N4, Canada
[11] Univ Sherbrooke, Fac Med & Hlth Sci, Sherbrooke, PQ J1H 5N4, Canada
关键词
COVID-19; post-acute COVID-19 syndrome; health-related quality of life; risk factors;
D O I
10.3390/jcm12185939
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Lingering symptoms are frequently reported after acute SARS-CoV-2 infection, a condition known as post-COVID-19 condition (PCC). The duration and severity of PCC in immunologically naive persons remain unclear. Furthermore, the long-term consequences of these chronic symptoms on work and mental health are poorly documented. Objective: To determine the outcome, the risk factors, and the impact on work and mental health associated with post-COVID-19 symptoms. Methods: This prospective population-based study assessed acute COVID-19 symptoms and their evolution for up to nine months following infection. Individuals aged 18 years and older with COVID-19 in three Canadian regions between 1 November 2020 and 31 May 2021 were recruited. Participants completed a questionnaire that was either administered by trained student investigators over the phone or self-administered online. Results: A total of 1349 participants with a mean age of 46.6 +/- 16.0 years completed the questionnaire. Participants were mostly unvaccinated at the time of their COVID-19 episode (86.9%). Six hundred and twenty-two participants (48.0%) exhibited one symptom or more, at least three months post-COVID-19. Among participants with PCC, 23.0% to 37.8% experienced fatigue at the time of survey. Moreover, 6.1% expressed psychological distress. Risk factors for PCC and fatigue included female sex (OR = 1.996), higher number of symptoms (OR = 1.292), higher severity of episode (OR = 3.831), and having a mental health condition prior to the COVID-19 episode (OR = 5.155). Conclusions: In this multicenter cohort study, almost half (47%) of the participants reported persistent symptoms >3 months after acute infection. Baseline risk factors for PCC include female sex, number and severity of symptoms during acute infection, and a previous diagnosis of mental health disorder. Having PCC negatively impacted health-related quality of life and these patients were more likely to exhibit psychological distress, as well as fatigue.
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