Sexual function and quality of life in women with idiopathic premature ovarian insufficiency

Background: Premature ovarian insufficiency (POI) is a disruptive diagnosis for women, with major consequences on fertility but also on quality of life and sexual functioning. Aim: The aim of this study was to evaluate the impact of vaginal symptoms from the genitourinary syndrome of menopause on the quality of life and sexual functioning of women with POI. Methods: This cross-sectional observational study involved 88 women who were investigated in a specialized setting at the University Hospital of Toulouse (France) between 2014 and 2019. All women completed the Day-to-Day Impact of Vaginal Aging (DIVA) questionnaire on well-being and quality of life and the Female Sexual Function Index (FSFI) on sexual functioning. Analysis of total scores and subdomains of the questionnaire was performed and compared according to use of hormone replacement therapy or local low-dose estrogen treatment, age at POI, and use of antidepressant therapy or current psychological support. Outcomes: Outcomes included the DIVA questionnaire and the FSFI. Results: Among the 88 women who fulfilled the inclusion criteria, 66 (75%) answered the questionnaires. Mean SD age at POI diagnosis was 32.6 6.9 years and mean age at questionnaire time was 41.6 6.9 years. The highest mean scores on the DIVA questionnaire were found in the self-perception and body image domain (2.05 +/- 1.36), followed by the sexual functioning domain (1.52 +/- 1.28). The mean FSFI score was 23.08 (95% CI, 21.43-24.73), with 32 women (78% of sexually active women) having a score <26.55, which defines sexual dysfunction. There was no difference in the FSFI score and for all DIVA domains whether or not women were taking hormone replacement therapy or local hormone therapy. Clinical Implications: This should encourage practitioners to systematically discuss the impact of POI on sexuality and vulvovaginal symptoms to provide women with specific care and advice to improve their quality of life. Strengths and Limitations: This is the first French study that aimed to assess the impact of the genitourinary syndrome of menopause on the quality of life and sexual well-being in women with POI by using standardized validated questionnaires with a very good participation rate (75%). The sample size was limited, and we could not eliminate selection bias due to university hospital recruitment. Conclusion: POI can have a negative impact on sexual quality of life, which raises the needs for specific advice and care.