Cell-free DNA approaches for cancer early detection and interception

被引：29
作者：
Medina, Jamie E. [1 ]
Dracopoli, Nicholas C. [2 ]
Bach, Peter B. [2 ]
Lau, Anna [2 ]
Scharpf, Robert B. [1 ]
Meijer, Gerrit A. [3 ]
Andersen, Claus Lindbjerg [4 ]
Velculescu, Victor E. [1 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Baltimore, MD 21218 USA
[2] Delfi Diagnost Inc, Baltimore, MD USA
[3] Netherlands Canc Inst, Amsterdam, Netherlands
[4] Aarhus Univ, Dept Clin Med, Aarhus, Denmark
来源：
JOURNAL FOR IMMUNOTHERAPY OF CANCER | 2023年 / 11卷 / 09期
基金：
美国国家卫生研究院;
关键词：
Biomarkers; Tumor; Neoplastic Cells; Circulating; Review; CIRCULATING TUMOR DNA; MUTATIONAL SIGNATURES; LUNG-CANCER; PLASMA; METHYLATION; MORTALITY; PROSTATE; VALIDATION; PRINCIPLES; PATTERNS;
D O I：
10.1136/jitc-2022-006013
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Rapid advancements in the area of early cancer detection have brought us closer to achieving the goals of finding cancer early enough to treat or cure it, while avoiding harms of overdiagnosis. We evaluate progress in the development of early cancer detection tests in the context of the current principles for cancer screening. We review cell-free DNA (cfDNA)-based approaches using mutations, methylation, or fragmentomes for early cancer detection. Lastly, we discuss the challenges in demonstrating clinical utility of these tests before integration into routine clinical care.
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页数：12
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