Epidermal Wearable Biosensors for the Continuous Monitoring of Biomarkers of Chronic Disease in Interstitial Fluid

被引：15

作者：

Yuan, Xichen ^{[1
,2
,3
]}

Ouaskioud, Oumaima ^{[1
,3
]}

Yin, Xu ^{[2
]}

Li, Chen ^{[1
,3
]}

Ma, Pengyi ^{[1
,3
]}

Yang, Yang ^{[4
]}

Yang, Peng-Fei ^{[1
,3
]}

Xie, Li ^{[3
]}

Ren, Li ^{[1
,3
]}

机构：

[1] Northwestern Polytech Univ, Key Lab Flexible Elect Zhejiang Prov, Ningbo Inst, Ningbo 315103, Peoples R China

[2] Northwestern Polytech Univ, Sch Mech Engn, MOE Key Lab Micro & Nano Syst Aerosp, Xian 710072, Peoples R China

[3] Northwestern Polytech Univ, Sch Life Sci, Key Lab Space Biosci & Biotechnol, Xian 710072, Peoples R China

[4] Chongqing Univ, Key Lab Low Grade Energy Utilizat Technol & Syst, Minist Educ, Chongqing 400030, Peoples R China

来源：

MICROMACHINES | 2023年 / 14卷 / 07期

基金：

中国国家自然科学基金;

关键词：

interstitial fluid; epidermis; wearable biosensor; chronic disease; TRANSDERMAL REVERSE IONTOPHORESIS; SALIVARY URIC-ACID; IN-VIVO; GLUCOWATCH(R) BIOGRAPHER; MOUTHGUARD BIOSENSOR; BLOOD-GLUCOSE; HUMAN SKIN; MICRODIALYSIS; EXTRACTION; DRUG;

D O I：

10.3390/mi14071452

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Healthcare technology has allowed individuals to monitor and track various physiological and biological parameters. With the growing trend of the use of the internet of things and big data, wearable biosensors have shown great potential in gaining access to the human body, and providing additional functionality to analyze physiological and biochemical information, which has led to a better personalized and more efficient healthcare. In this review, we summarize the biomarkers in interstitial fluid, introduce and explain the extraction methods for interstitial fluid, and discuss the application of epidermal wearable biosensors for the continuous monitoring of markers in clinical biology. In addition, the current needs, development prospects and challenges are briefly discussed.

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页数：24

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[11] Wearable Microneedle Patch for Transdermal Electrochemical Monitoring of Urea in Interstitial Fluid [J].

Dervisevic, Muamer ;

Jara Fornerod, Maximiliano Jesus ;

Harberts, Jann ;

Zangabad, Parham Sahandi ;

Voelcker, Nicolas H. .

ACS SENSORS, 2024, 9 (02) :932-941

[12] An integrated wearable differential microneedle array for continuous glucose monitoring in interstitial fluids [J].

Yang, Yong ;

Sheng, Can ;

Dong, Fang ;

Liu, Sheng .

BIOSENSORS & BIOELECTRONICS, 2024, 256

[13] Continuous monitoring of multiple biomarkers with an ultrasensitive 3D-structured wearable biosensor [J].

Yang, Muqun ;

Wang, Han ;

Cheng, Jing .

CELL REPORTS METHODS, 2023, 3 (09)

[14] Evaluation of cerebrospinal fluid (CSF) and interstitial fluid (ISF) mouse proteomes for the validation and description of Alzheimer's disease biomarkers [J].

Gorska, Anna Maria ;

Santos-Garcia, Irene ;

Eiriz, Ivan ;

Bruning, Thomas ;

Nyman, Tuula ;

Pahnke, Jens .

JOURNAL OF NEUROSCIENCE METHODS, 2024, 411

[15] Wearable microneedle array-based sensor for transdermal monitoring of pH levels in interstitial fluid [J].

Dervisevic, Muamer ;

Dervisevic, Esma ;

Esser, Lars ;

Easton, Christopher D. ;

Cadarso, Victor J. ;

Voelcker, Nicolas H. .

BIOSENSORS & BIOELECTRONICS, 2023, 222

[16] Monitoring drug pharmacokinetics and immunologic biomarkers in dermal interstitial fluid using a microneedle patch [J].

Chandana Kolluru ;

Mikayla Williams ;

Jihee Stephanie Yeh ;

Richard K. Noel ;

Jennifer Knaack ;

Mark R. Prausnitz .

Biomedical Microdevices, 2019, 21

[17] From population-based to personalized laboratory medicine: continuous monitoring of individual laboratory data with wearable biosensors [J].

Coskun, Abdurrahman ;

Savas, Irem Nur ;

Can, Ozge ;

Lippi, Giuseppe .

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2025, 62 (03) :198-227

[18] Recent advances in wearable biosensors for non-invasive monitoring of specific metabolites and electrolytes associated with chronic kidney disease: Performance evaluation and future challenges [J].

Kukkar, Deepak ;

Zhang, Daohong ;

Jeon, B. H. ;

Kim, Ki-Hyun .

TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2022, 150

[19] An Interstitial Fluid Transdermal Extraction Chip with Vacuum Generator and Volume Sensor for Continuous Glucose Monitoring [J].

Yu, Haixia ;

Li, Dachao ;

Ji, Yongjie ;

Zhang, Xiaoli ;

Xu, Kexin .

MICRO-NANO TECHNOLOGY XIV, PTS 1-4, 2013, 562-565 :571-575

[20] Continuous Monitoring of Interstitial Fluid Glucose Responses to Endurance Exercise with Different Levels of Carbohydrate Intake [J].

Hiromatsu, Chiyori ;

Kasahara, Naoto ;

Lin, Chao-An ;

Wang, Feifei ;

Goto, Kazushige .

NUTRIENTS, 2023, 15 (22)