[1] Univ Grenoble Alpes, Grenoble Inst Neurosci, CHU Grenoble Alpes, Inserm, F-38000 Grenoble, France
[2] Guys & St ThomasNHS Fdn Trust, Ctr Thrombosis & Haemophilia, Westminster Bridge Rd, London SE1 7EH, England
[3] Erasmus MC, Dept Intens Care, Lab Translat Intens Care, Rotterdam, Netherlands
[4] Hop Albert Michallon, Pole Anesthesie Reanimat, BP 217, F-38043 Grenoble, France
[5] Univ Grenoble Alpes, Grenoble Inst Neurosci, CHU Grenoble Alpes, Inserm, F-38000 Grenoble, France