A human pan-cancer system analysis of regulator of chromatin condensation 2

被引：1

作者：

Gong, Siming ^{[1
,2
,3
]}

Wu, Hao ^{[4
]}

Wu, Changwu ^{[3
]}

Duan, Yingjuan ^{[5
]}

Zhang, Bixi ^{[6
]}

Wu, Panfeng ^{[1
,2
]}

Tang, Juyu ^{[1
,2
]}

Fu, Jinfei ^{[1
,2
]}

机构：

[1] Cent South Univ, Xiangya Hosp, Dept Orthpaed, Changsha, Peoples R China

[2] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China

[3] Univ Leipzig, Inst Anat, Leipzig, Germany

[4] Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha, Peoples R China

[5] Univ Leipzig, Fac Chem & Mineral, Leipzig, Germany

[6] Hunan Normal Univ, Hunan Prov Peoples Hosp, Dept Pathol, Changsha, Peoples R China

来源：

HELIYON | 2023年 / 9卷 / 02期

基金：

中国国家自然科学基金;

关键词：

RCC2; Prognosis; Immune infiltration; Enrichment analysis; Immune checkpoint inhibitor; Pan -cancer analysis; EPITHELIAL-MESENCHYMAL TRANSITION; CELLS; PROGRESSION; EXPRESSION; TARGET; RCC2; BLOCKADE; SURVIVAL; TD-60; GENE;

D O I：

10.1016/j.heliyon.2023.e13599

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Regulation of chromosome condensation 2 (RCC2) is associated with the cell cycle and is a crucial regulator of the chromatin condensation 1 (RCC1) family. The members of this family were normally regulators in the process of DNA replication and nucleocytoplasmic transport. RCC2 overexpression may lead to tumor formation and poor prognosis in some tumors including breast cancer and lung adenocarcinoma. However, the possible role of RCC2 in tumor formation and its prognostic function remains unclear. In this study, expression analysis from databases including The Cancer Genome Atlas (TCGA) and Clinical Proteomic Tumor Analysis Consortium (CPTAC) were combined to perform the first integrative and comprehensive analysis of RCC2 in human pan-cancer. RCC2 was highly expressed in most tumors which may lead to a poor prognosis. RCC2 expression was associated with immune/stromal infiltration, immune checkpoints, tumor mutational burden, and microsatellite instability. Thus, RCC2 could be a novel biomarker for prognosis and a promising cancer therapy target.

引用

页数：12

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