Evidence-Based Approach to Orthobiologics for Osteoarthritis and Other Joint Disorders

OA is a raising burden and many possibilities to treat cartilage lesions and early OA have been reported. To treat cartilage defects, cell therapies using chondrocytes, MSCs, and other cell sources have been used. To obtain the best cartilage quality, these cartilage preserving/regenerating techniques combined with alignment correction osteotomy will give the best results. The biology of the articular cartilage must be fully explained before cartilage repair technologies can advance further. Collecting evidence of experimental studies on cartilage repair and early OA treatment will enable us to develop a clinical use of novel techniques for biological healing. Therefore, the use of the most appropriate line of treatment and proper patient selection is key to improving results.