Antibacterial functionalized carbon dots and their application in bacterial infections and inflammation

Bacterial infections and inflammation pose a severe threat to human health and the social economy. The existence of super-bacteria and the increasingly severe phenomenon of antibiotic resistance highlight the development of new antibacterial agents. Due to low cytotoxicity, high biocompatibility, and different antibacterial mechanisms from those for antibiotics, functionalized carbon dots (FCDs) promise a new platform for the treatment of bacterial infectious diseases. However, few articles have systematically sorted out the available antibacterial mechanisms for FCDs and their application in the treatment of bacterial inflammation. This review focuses on the available antibacterial mechanisms for FCDs, including covalent and non-covalent interactions, reactive oxygen species, photothermal therapy, and size effect. Meanwhile, the design of antibacterial FCDs is introduced, including surface modification, doping, and combination with other nanomaterials. Furthermore, this review specifically concentrates on the research advances of antibacterial FCDs in the treatment of bacterial inflammation. Finally, the advantages and challenges of applying FCDs in practical antimicrobial applications are discussed. Antimicrobial mechanisms of functionalized carbon dots: covalent and non-covalent interactions, reactive oxygen species, photothermal effect, and size effect (E. coli was used as a model).