Role of selenium in type 2 diabetes, insulin resistance and insulin secretion

被引：20
作者：
Casanova, Pilar [1 ]
Monleon, Daniel [1 ]
机构：
[1] Univ Valencia, Dept Pathol, 15 Avda Blasco Ibanez, Valencia 46010, Spain
来源：
WORLD JOURNAL OF DIABETES | 2023年 / 14卷 / 03期
关键词：
Selenium; Diabetes; Insulin resistance; Metabolism; Antioxidants; SUPPLEMENTATION; RISK; METABOLISM; SELENOPROTEINS; ASSOCIATION; DYSFUNCTION;
D O I：
10.4239/wjd.v14.i3.147
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Selenium is a trace mineral essential for life that acts physiologically through selenoproteins. Among other actions, the endogenous antioxidant selenoprotein glutathione peroxidase and the selenium transporter in blood, selenoprotein P, seem to play an important role in type 2 diabetes mellitus and insulin resistance by weakening the insulin signaling cascade through different mechanisms. Recent findings also suggest that selenoproteins also affect insulin biosynthesis and insulin secretion. This review discussed the role of selenium in type 2 diabetes and the complex interplay between selenoproteins and insulin pathways.
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页数：13
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