Role of selenium in type 2 diabetes, insulin resistance and insulin secretion

被引：16
|
作者：
Casanova, Pilar [1 ]
Monleon, Daniel [1 ]
机构：
[1] Univ Valencia, Dept Pathol, 15 Avda Blasco Ibanez, Valencia 46010, Spain
来源：
WORLD JOURNAL OF DIABETES | 2023年 / 14卷 / 03期
关键词：
Selenium; Diabetes; Insulin resistance; Metabolism; Antioxidants; SUPPLEMENTATION; RISK; METABOLISM; SELENOPROTEINS; ASSOCIATION; DYSFUNCTION;
D O I：
10.4239/wjd.v14.i3.147
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Selenium is a trace mineral essential for life that acts physiologically through selenoproteins. Among other actions, the endogenous antioxidant selenoprotein glutathione peroxidase and the selenium transporter in blood, selenoprotein P, seem to play an important role in type 2 diabetes mellitus and insulin resistance by weakening the insulin signaling cascade through different mechanisms. Recent findings also suggest that selenoproteins also affect insulin biosynthesis and insulin secretion. This review discussed the role of selenium in type 2 diabetes and the complex interplay between selenoproteins and insulin pathways.
引用
收藏
页数：13
相关论文
共 50 条
  • [1] The role of insulin secretion and resistance in the pathogenesis of type 2 diabetes in Chinese
    Jia, WP
    Xiang, KS
    Lu, JX
    Zheng, YM
    Tang, JL
    DIABETOLOGIA, 1998, 41 : A197 - A197
  • [2] Disordered insulin secretion in the development of insulin resistance and Type 2 diabetes
    Schofield, C. J.
    Sutherland, C.
    DIABETIC MEDICINE, 2012, 29 (08) : 972 - 979
  • [3] Type 2 diabetes: When insulin secretion fails to compensate for insulin resistance
    Kahn, BB
    CELL, 1998, 92 (05) : 593 - 596
  • [4] Cerebral Regulation of Insulin Secretion and the Development of Insulin Resistance in Type 2 Diabetes
    Wasilewska, Marta
    Adamiec, Rajmund
    ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, 2012, 21 (06): : 695 - 703
  • [5] Type 2 diabetes - Insulin secretion, insulin sensitivity
    Solignac, M
    DIABETES & METABOLISM, 1999, 25 (02)
  • [6] Characterization of insulin secretion and resistance in type 2 diabetes of adolescents
    Druet, C
    Tubiana-Rufi, N
    Chevenne, D
    Rigal, O
    Polak, M
    Levy-Marchal, C
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (02): : 401 - 404
  • [7] Pathogenesis of type 2 diabetes: the relative contribution of insulin resistance and impaired insulin secretion
    Groop, L
    INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2000, : 3 - 13
  • [8] Leptin levels in type 2 diabetes: Associations with measures of insulin resistance and insulin secretion
    Wauters, M
    Considine, RV
    Yudkin, JS
    Peiffer, F
    De Leeuw, I
    Van Gaal, LF
    HORMONE AND METABOLIC RESEARCH, 2003, 35 (02) : 92 - 96
  • [9] The role of PPAR γ in insulin resistance and type 2 diabetes
    Hara, K
    Tobe, K
    Okada, T
    Mori, Y
    Yasuda, K
    Kadowaki, H
    Hagura, R
    Akanuma, Y
    Ito, C
    Kadowaki, T
    DIABETES, 2000, 49 : A204 - A204
  • [10] Effects of insulin resistance and insulin secretion on the development of type Ⅱ diabetes mellitus
    李光伟
    胡英华
    杨文英
    中华内科杂志, 1998, (Z1)
12345