The emerging role of the piRNA/PIWI complex in respiratory tract diseases

被引：9

作者：

Yao, Yizhu ^{[1
]}

Li, Yaozhe ^{[1
]}

Zhu, Xiayan ^{[1
]}

Zhao, Chengguang ^{[1
,2
]}

Yang, Lehe ^{[1
]}

Huang, Xiaoying ^{[1
]}

Wang, Liangxing ^{[1
]}

机构：

[1] Wenzhou Med Univ, Affiliated Hosp 1, Div Pulm Med, Wenzhou 325000, Zhejiang, Peoples R China

[2] Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China

来源：

RESPIRATORY RESEARCH | 2023年 / 24卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Non-coding RNAs; PIWI protein; PIWI-interacting RNA; Respiratory tract diseases; PIWI-INTERACTING RNAS; PULMONARY ARTERIAL-HYPERTENSION; MOLECULAR-BASIS; DROSOPHILA PIWI; WEB RESOURCE; LUNG-CANCER; PIRNAS; BIOGENESIS; PROTEINS; PATHWAY;

D O I：

10.1186/s12931-023-02367-9

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

PIWI-interacting RNA (piRNA) is a class of recently discovered small non-coding RNA molecules with a length of 18-33 nt that interacts with the PIWI protein to form the piRNA/PIWI complex. The PIWI family is a subfamily of Argonaute (AGO) proteins that also contain the AGO family which bind to microRNA (miRNA). Recently studies indicate that piRNAs are not specific to in the mammalian germline, they are also expressed in a tissue-specific manner in a variety of human tissues and participated in various of diseases, such as cardiovascular, neurological, and urinary tract diseases, and are especially prevalent in malignant tumors in these systems. However, the functions and abnormal expression of piRNAs in respiratory tract diseases and their underlying mechanisms remain incompletely understood. In this review, we discuss current studies summarizing the biogenetic processes, functions, and emerging roles of piRNAs in respiratory tract diseases, providing a reference value for future piRNA research.

引用

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