Anti-inflammatory Clerodane Diterpenoids from Polyalthia longifolia

被引：3
|
作者：
Yu Zhangxin [1 ,2 ]
Song Xinming [1 ,2 ]
Yao Yuan [1 ,2 ]
Yang Jun [1 ,2 ]
Yang Shuo [1 ,2 ]
Li Xiaobao [1 ,2 ]
机构：
[1] Hainan Normal Univ, Key Lab Trop Med Resource Chem, Minist Educ, Haikou 571158, Hainan, Peoples R China
[2] Hainan Normal Univ, Coll Chem & Chem Engn, Key Lab Trop Med Plant Chem Hainan Prov, Haikou 571158, Hainan, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 43卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Polyalthia longifolia; clerodane diterpenes; anti-inflammatory; ALKALOIDS;
D O I：
10.6023/cjoc202208019
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Four new clerodane diterpenoids (1 similar to 4) were obtained from the stems of Polyalthia longifolia during a systematic phytochemical investigation. Their structures were elucidated comprehensive spectroscopic methods as 2-oxo-14,15,16-tri-norclerod3-en-13-oic acid (1), 2-oxo-14,15,16-trinorclerod-3-en-13-methyl ester (2), 2-oxo-14,15,16-trinorclerod-3,11Edien-13-oic acid (3), and 2-oxo-cleroda-3,13Z-dien-16-hydroxy-15-oic acid (4). Among them, compounds 1 similar to 3 are 14,15,16-norclerodane diterpenoids. The anti-inflammatory activity of mouse leukemia cells of monocyte macrophage (RAW 264.7) cells with lipopolysaccharide-induced was evaluated, and all the compounds showed potential anti-inflammatory activities with IC50 values ranged from 9.24 to18.82 mu mol/L.
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页码：751 / 755
页数：5
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