Pullulan in pharmaceutical and cosmeceutical formulations: A review

被引:52
作者
Singh, Ram Sarup [1 ,2 ]
Kaur, Navpreet [1 ]
Singh, Dhandeep [3 ]
Purewal, Sukhvinder Singh [2 ]
Kennedy, John F. [4 ]
机构
[1] Punjabi Univ, Dept Biotechnol, Carbohydrates & Prot Biotechnol Lab, Patiala 147002, Punjab, India
[2] Chandigarh Univ, Univ Ctr Res & Dev UCRD, Mohali 140413, Punjab, India
[3] Punjabi Univ, Dept Pharmaceut Sci, Patiala 147002, Punjab, India
[4] Chembiotech Labs Ltd, Tenbury Wells WR15 8SG, England
关键词
Pullulan; Pharmaceutical; Cosmeceuticals; Drug carrier; PULSED-LASER EVAPORATION; EXTRACELLULAR GLUCAN; DISSOLVING FILMS; GENE DELIVERY; DRUG-RELEASE; THIN-FILMS; NANOPARTICLES; POLYSACCHARIDE; HYDROGEL; PH;
D O I
10.1016/j.ijbiomac.2023.123353
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Pullulan, an alpha-glucan polysaccharide, is colorless, odorless, non-toxic, non-carcinogenic, highly biocompatible, edible and biodegradable in nature. The long chains of glucopyranose rings in pullulan structure are linked together by alpha-(1-+ 4) and alpha-(1-+ 6) glycosidic linkages. The occurrence of both glycosidic linkages in the pullulan structure contributes to its distinctive properties. The unique structure of pullulan makes it a potent candidate for both pharmaceutical and cosmeceutical applications. In pharmaceuticals, it can be used as a drug carrier and in various dosage formulations. It has been widely used in drug targeting, implants, ocular dosage forms, topical formulations, oral dosage forms, and oral liquid formulations, etc. Pullulan can be used as a po-tential carrier of active ingredients and their site-specific delivery to skin layers for cosmeceutical applications. It has been extensively used in cosmeceutical formulations like creams, shampoo, lotions, sunscreen, facial packs, etc. The current review highlights applications of pullulan in pharmaceutical and cosmeceutical applications.
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页数:10
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