Selective Syntheses of Coumarin and Benzofuran Derivatives Using Phenols and α-Methoxy-β-ketoesters

被引：1

作者：

Miyata, Ryo ^{[1
]}

Shigeta, Takashi ^{[1
]}

Kumazawa, Shigenori ^{[1
]}

Egi, Masahiro ^{[1
]}

机构：

[1] Univ Shizuoka, Grad Sch Integrated Pharmaceut & Nutr Sci, 52-1 Yada,Suruga Ku, Shizuoka 4228526, Japan

来源：

SYNOPEN | 2023年 / 07卷 / 01期

基金：

日本学术振兴会;

关键词：

coumarin; benzofuran; selective syntheses; phenol; alpha-methoxy-beta-ketoester; alpha-methoxyacetophenone; CATALYZED SYNTHESIS; ANTIOXIDANT; CYCLIZATION; ANALOGS;

D O I：

10.1055/s-0042-1751408

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Selective syntheses of coumarin and benzofuran derivatives were achieved via HClO4-mediated intermolecular annulation using phenols and a-methoxy-13-ketoesters. Coumarins are formed under dehydrated conditions, whereas benzofurans are formed in the presence of water. In the synthetic process of benzofurans, a-methoxy-13-ketoesters are converted into a-methoxyacetophenones, and the methoxy group is an important element in the intermolecular annulation.

引用

页码：8 / 16

页数：9

共 47 条

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