Synthesis and characterization of two piperazine containing macrocycles and their transition metal complexes

被引：2

作者：

Pota, Kristof ^{[1
]}

Johnston, Hannah M. ^{[1
]}

Madarasi, Eniko ^{[2
,3
]}

Tircso, Gyula ^{[2
]}

Green, Kayla N. ^{[1
]}

机构：

[1] Texas Christian Univ, Dept Chem & Biochem, 2950 W Bowie, Ft Worth, TX 76129 USA

[2] Univ Debrecen, Fac Sci & Technol, Dept Phys Chem, Egyet Ter 1, H-4032 Debrecen, Hungary

[3] Univ Debrecen, Doctoral Sch Chem, Egyet Ter 1, H-4032 Debrecen, Hungary

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2023年 / 241卷

关键词：

Piperazine; Macrocycle; Manganese; Log B; Pyridinophane; MOLECULAR-MECHANICS; CRYSTAL-STRUCTURE; MN2+ COMPLEXES; SCHIFF-BASES; LIGANDS; STABILITY; PYRIDINE; CONFORMATION; PROTONATION; RELAXATION;

D O I：

10.1016/j.jinorgbio.2023.112124

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rigidification of the ligand scaffolds has been a particular mechanism of interest employed to achieve properties suitable for MRI contrast, catalysis, or other applications of metal complexes. Towards the goal of targeting a 15-anePyN5Pip type ligand, a serendipitous isolation of a 30-anePy2N10Pip2 aza-macrocycle was achieved, instead. X-ray diffraction and determination of pKa events were carried out and compared to 17-anePyN5Pip. Further-more, the X-ray diffraction of the Cu(II) and Zn(II) complexes of 17-anePyN5Pip was achieved and compared to previous reports of other first-row transition metal derivatives of this ligand. Determination of the log beta with both 30-anePy2N10Pip2 and 17-anePyN5Pip with the divalent Mn-Zn metal-ion series was used to demonstrate the impact that the piperazine ring plays compared to other, less rigid macrocycles reported to date.

引用

页数：9

共 57 条

[1] SYNTHESIS, STRUCTURE, AND SPECTROSCOPIC PROPERTIES OF COPPER(II) COMPOUNDS CONTAINING NITROGEN SULFUR DONOR LIGANDS - THE CRYSTAL AND MOLECULAR-STRUCTURE OF AQUA[1,7-BIS(N-METHYLBENZIMIDAZOL-2'-YL)-2,6-DITHIAHEPTANE]COPPER(II) PERCHLORATE [J].