A combination model of AD biomarkers revealed by machine learning precisely predicts Alzheimer's dementia: China Aging and Neurodegenerative Initiative (CANDI) study

被引：45

作者：

Gao, Feng ^{[1
,2
]}

Lv, Xinyi ^{[1
]}

Dai, Linbin ^{[1
,2
]}

Wang, Qiong ^{[1
,2
]}

Wang, Peng ^{[3
]}

Cheng, Zhaozhao ^{[1
]}

Xie, Qiang ^{[4
]}

Ni, Ming ^{[4
]}

Wu, Yan ^{[1
]}

Chai, Xianliang ^{[1
]}

Wang, Wenjing ^{[1
]}

Li, Huaiyu ^{[1
]}

Yu, Feng ^{[1
]}

Cao, Yuqin ^{[1
]}

Tang, Fang ^{[1
]}

Pan, Bo ^{[4
]}

Wang, Guoping ^{[1
]}

Deng, Kexue ^{[3
]}

Wang, Shicun ^{[4
]}

Tang, Qiqiang ^{[1
]}

Shi, Jiong ^{[5
]}

Shen, Yong ^{[1
,2
]}

机构：

[1] Univ Sci & Technol China, Affiliated Hosp USTC 1, Div Life Sci & Med, Dept Neurol,Inst Aging & Brain Disorders, Hefei, Peoples R China

[2] Univ Sci & Technol China, Neurodegenerat Disorder Res Ctr, Div Life Sci & Med, Anhui Prov Key Lab Biomed Aging Res, Hefei, Peoples R China

[3] Univ Sci & Technol China, Affiliated Hosp USTC 1, Div Life Sci & Med, Dept Radiol, Hefei, Peoples R China

[4] Univ Sci & Technol China, Affiliated Hosp USTC 1, Div Life Sci & Med, Dept Nucl Med, Hefei, Peoples R China

[5] Capital Med Univ, Beijing Tiantan Hosp, China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China

来源：

ALZHEIMERS & DEMENTIA | 2023年 / 19卷 / 03期

关键词：

Alzheimer's disease; amyloid PET; fluid biomarker; MRI; MILD COGNITIVE IMPAIRMENT; BRAIN ATROPHY; AMYLOID-PET; DISEASE; AGE; DEFINITION; DIAGNOSIS; HISTORY; ONSET; CSF;

D O I：

10.1002/alz.12700

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction To test the utility of the "A/T/N" system in the Chinese population, we study core Alzheimer's disease (AD) biomarkers in a newly established Chinese cohort. Methods A total of 411 participants were selected, including 96 cognitively normal individuals, 94 patients with mild cognitive impairment (MCI) patients, 173 patients with AD, and 48 patients with non-AD dementia. Fluid biomarkers were measured with single molecule array. Amyloid beta (A beta) deposition was determined by F-18-Flobetapir positron emission tomography (PET), and brain atrophy was quantified using magnetic resonance imaging (MRI). Results A beta 42/A beta 40 was decreased, whereas levels of phosphorylated tau (p-tau) were increased in cerebrospinal fluid (CSF) and plasma from patients with AD. CSF A beta 42/A beta 40, CSF p-tau, and plasma p-tau showed a high concordance in discriminating between AD and non-AD dementia or elderly controls. A combination of plasma p-tau, apolipoprotein E (APOE) genotype, and MRI measures accurately predicted amyloid PET status. Discussion These results revealed a universal applicability of the "A/T/N" framework in a Chinese population and established an optimal diagnostic model consisting of cost-effective and non-invasive approaches for diagnosing AD.

引用

页码：749 / 760

页数：12

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