α-Acyloxylation of Ketones/Cyclic Ethers Mediated by Hypervalent Iodine(III) Reagents as Oxidants and Nucleophilic Sources

被引：2

作者：

Jia, Hao ^{[1
]}

Li, Nan ^{[1
]}

Tang, Chunmei ^{[1
]}

Ni, Wenjing ^{[1
]}

Zhao, Xinru ^{[1
]}

Sun, Jing ^{[1
]}

Wu, Fufang ^{[1
]}

Shen, Xiaobao ^{[1
]}

Zhai, Hongbin ^{[2
]}

机构：

[1] Fuyang Normal Univ, Engn Res Ctr Biomass Convers & Pollut Prevent Anhu, Biomass Oligosaccharides Engn Technol Res Ctr Anhu, Fuyang 236037, Peoples R China

[2] Shenzhen Polytech, Inst Marine Biomed, Shenzhen 518055, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 03期

基金：

中国国家自然科学基金;

关键词：

C-H BONDS; CARBOXYLIC-ACIDS; DIRECT ESTERIFICATION; CARBONYL-COMPOUNDS; BENZOYLOXYLATION; OXYACYLATION; GENERATION; COMPLEXES;

D O I：

10.1021/acs.joc.3c02526

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This study describes a catalyst-free alpha-acyloxylation of ketones and a KBr-mediated alpha-acyloxylation of cyclic ethers. These conversions are effectively mediated by hypervalent iodine-(III) reagents serving dual roles as the oxidant and nucleophilic source. Consequently, esters are produced directly in moderate to excellent yields. The proposed method features good functional group compatibility, a broad substrate scope, and high synthetic efficiency and is remarkably environmentally friendly.

引用

页码：2055 / 2063

页数：9

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