Emerging therapeutic options for refractory gout

被引：5

作者：

Jatuworapruk, Kanon ^{[1
]}

Louthrenoo, Worawit ^{[2
]}

机构：

[1] Thammasat Univ, Fac Med, Dept Med, Div Rheumatol, Pathum Thani, Thailand

[2] Chiang Mai Univ, Fac Med, Dept Internal Med, Div Rheumatol, Chiang Mai, Thailand

来源：

NATURE REVIEWS RHEUMATOLOGY | 2024年 / 20卷 / 02期

关键词：

D O I：

10.1038/s41584-023-01066-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

For individuals with gout, the treatment options beyond conventional urate-lowering therapies are expanding. Notable advancements in 2023 include developments in uricase therapy, new xanthine oxidase inhibitors, and a class of medications that offer dual benefits for the control of type 2 diabetes mellitus and gout. Co-administration of methotrexate or rapamycin-containing nanoparticles enhances the long-term effectiveness of uricase therapy by suppressing the production of anti-drug antibodies3,5.Tigulixostat, a xanthine oxidase inhibitor, has demonstrated high urate-lowering efficacy and a good safety profile compared with placebo, but head-to-head comparison to allopurinol is still required6.Sodium-glucose cotransporter-2 (SGLT2) inhibitors provide dual benefits as they not only serve as antidiabetic therapies but also reduce serum urate concentrations and the risk of gout flare8,9.

引用

页码：73 / 74

页数：2

共 10 条

[1] The COMPARE head-to-head, randomized controlled trial of SEL-212 (pegadricase plus rapamycin-containing nanoparticle, ImmTOR™) versus pegloticase for refractory gout [J].

Baraf, Herbert S. B. ;

Khanna, Puja P. ;

Kivitz, Alan J. ;

Strand, Vibeke ;

Choi, Hyon K. ;

Terkeltaub, Robert ;

Dalbeth, Nicola ;

DeHaan, Wesley ;

Azeem, Rehan ;

Traber, Peter G. ;

Keenan, Robert T. .

RHEUMATOLOGY, 2024, 63 (04) :1058-1067

[2] A Randomized, Double-Blind, Placebo-Controlled Multicenter Efficacy and Safety Study of Methotrexate to Increase Response Rates in Patients With Uncontrolled Gout Receiving Pegloticase: 12-Month Findings [J].

Botson, John K. ;

Saag, Kenneth ;

Peterson, Jeff ;

Obermeyer, Katie ;

Xin, Yan ;

LaMoreaux, Brian ;

Padnick-Silver, Lissa ;

Verma, Supra ;

Grewal, Suneet ;

Majjhoo, Amar ;

Tesser, John R. P. ;

Weinblatt, Michael E. .

ACR OPEN RHEUMATOLOGY, 2023, 5 (08) :407-418

[3] A Randomized, Placebo-Controlled Study of Methotrexate to Increase Response Rates in Patients with Uncontrolled Gout Receiving Pegloticase: Primary Efficacy and Safety Findings [J].

Botson, John K. ;

Saag, Kenneth ;

Peterson, Jeff ;

Parikh, Naval ;

Ong, Stephen ;

La, Dan ;

LoCicero, Karon ;

Obermeyer, Katie ;

Xin, Yan ;

Chamberlain, Jason ;

LaMoreaux, Brian ;

Verma, Supra ;

Sainati, Stephen ;

Grewal, Suneet ;

Majjhoo, Amar ;

Tesser, John R. P. ;

Weinblatt, Michael E. .

ARTHRITIS & RHEUMATOLOGY, 2023, 75 (02) :293-304

[4] 2020 American College of Rheumatology Guideline for the Management of Gout [J].

FitzGerald, John D. ;

Dalbeth, Nicola ;

Mikuls, Ted ;

Brignardello-Petersen, Romina ;

Guyatt, Gordon ;

Abeles, A. M. ;

Gelber, Allan C. ;

Harrold, Leslie R. ;

Khanna, Dinesh ;

King, Charles ;

Levy, Gerald ;

Libbey, Caryn ;

Mount, David ;

Pillinger, Michael H. ;

Rosenthal, Ann ;

Singh, Jasvinder A. ;

Sims, James Edward ;

Smith, Benjamin J. ;

Wenger, Neil S. ;

Bae, Sangmee Sharon ;

Danve, Abhijeet ;

Khanna, Puja P. ;

Kim, Seoyoung C. ;

Lenert, Aleksander ;

Poon, Samuel ;

Qasim, Anila ;

Sehra, Shiv T. ;

Sharma, Tarun Sudhir Kumar ;

Toprover, Michael ;

Turgunbaev, Marat ;

Zeng, Linan ;

Zhang, Mary Ann ;

Turner, Amy S. ;

Neogi, Tuhina .

ARTHRITIS & RHEUMATOLOGY, 2020, 72 (06) :879-895

[5] Phase 2 Dose-Finding Study in Patients with Gout Using SEL-212, a Novel PEGylated Uricase (SEL-037) Combined with Tolerogenic Nanoparticles (SEL-110) [J].

Kivitz, Alan ;

DeHaan, Wesley ;

Azeem, Rehan ;

Park, Justin ;

Rhodes, Sheri ;

Inshaw, Jamie ;

Leung, Sheldon S. ;

Nicolaou, Savvas ;

Johnston, Lloyd ;

Kishimoto, Takashi K. ;

Traber, Peter G. ;

Sands, Earl ;

Choi, Hyon .

RHEUMATOLOGY AND THERAPY, 2023, 10 (04) :825-847

[6] Comparative Effectiveness of Sodium-Glucose Cotransporter-2 Inhibitors for Recurrent Gout Flares and Gout-Primary Emergency Department Visits and Hospitalizations A General Population Cohort Study [J].

McCormick, Natalie ;

Yokose, Chio ;

Wei, Jie ;

Lu, Na ;

Wexler, Deborah J. ;

Avina-Zubieta, J. Antonio ;

De Vera, Mary A. ;

Zhang, Yuqing ;

Choi, Hyon K. .

ANNALS OF INTERNAL MEDICINE, 2023, 176 (08) :1067-+

[7] Serum Urate-Lowering Efficacy and Safety of Tigulixostat in Gout Patients With Hyperuricemia: A Randomized, Double-Blind, Placebo-Controlled, Dose-Finding Trial [J].

Terkeltaub, Robert ;

Lee, Jisoo ;

Min, Jiyoung ;

Shin, Seonghye ;

Saag, Kenneth G. .

ARTHRITIS & RHEUMATOLOGY, 2023, 75 (07) :1275-1284

[8] Gout Flares and Mortality After Sodium-Glucose Cotransporter-2 Inhibitor Treatment for Gout and Type 2 Diabetes [J].

Wei, Jie ;

Choi, Hyon K. ;

Dalbeth, Nicola ;

Li, Xiaoxiao ;

Li, Changjun ;

Zeng, Chao ;

Lei, Guanghua ;

Zhang, Yuqing .

JAMA NETWORK OPEN, 2023, 6 (08) :E2330885

[9] Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout [J].

White, William B. ;

Saag, Kenneth G. ;

Becker, Michael A. ;

Borer, Jeffrey S. ;

Gorelick, Philip B. ;

Whelton, Andrew ;

Hunt, Barbara ;

Castillo, Majin ;

Gunawardhana, Lhanoo .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (13) :1200-1210

[10] Effect of sodium-glucose cotransporter-2 (SGLT2) inhibitors on serum urate levels in patients with and without diabetes: a systematic review and meta-regression of 43 randomized controlled trials [J].

Yip, Alicia Swee Yan ;

Leong, Shariel ;

Teo, Yao Hao ;

Teo, Yao Neng ;

Syn, Nicholas L. X. ;

See, Ray Meng ;

Wee, Caitlin Fern ;

Chong, Elliot Yeung ;

Lee, Chi-Hang ;

Chan, Mark Y. ;

Yeo, Tiong-Cheng ;

Wong, Raymond C. C. ;

Chai, Ping ;

Sia, Ching-Hui .

THERAPEUTIC ADVANCES IN CHRONIC DISEASE, 2022, 13

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