The Emerging Role of Liquid Biopsies in Revolutionising Cancer Diagnosis and Therapy

被引：32

作者：

Shegekar, Tejas ^{[1
]}

Vodithala, Sahitya ^{[2
,3
]}

Juganavar, Anup ^{[1
]}

机构：

[1] Jawaharlal Nehru Med Coll, Datta Meghe Inst Higher Educ & Res, Dept Med, Wardha, India

[2] Jawaharlal Nehru Med Coll, Datta Meghe Inst Higher Educ & Res, Dept Pathol, Wardha, India

[3] Jawaharlal Nehru Med Coll, Datta Meghe Inst Higher Educ & Res, Lab Med, Wardha, India

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2023年 / 15卷 / 08期

关键词：

colon cancer; lung cancer; breast cancer; clinical applications; micrornas; exosomes; circulating tumor cells (ctcs); circulating tumor dna (ctdna); cancer; liquid biopsy; CIRCULATING TUMOR-CELLS; RESISTANT PROSTATE-CANCER; DROPLET DIGITAL PCR; BREAST-CANCER; LUNG-CANCER; DNA; EXOSOMES; BIOMARKERS; MICRORNAS; CHALLENGES;

D O I：

10.7759/cureus.43650

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A potential non-invasive technique for identifying and tracking cancer is a liquid biopsy. This review article provides a comprehensive overview of the principles, applications, and challenges associated with liquid biopsies. The circulating tumour DNA (ctDNA), circulating tumour cells (CTCs), exosomes, and microRNAs are just a few of the biomarkers we cover in this article that are discovered in liquid biopsies. The clinical application of liquid biopsies in many stages of cancer management, including early cancer identification, therapy selection and response monitoring, and minimum residual illness, is also investigated. The technical advancements in liquid biopsy techniques, including digital polymerase chain reaction (dPCR) and next-generation sequencing (NGS), have improved the sensitivity and specificity of biomarker identification. Liquid biopsies require assistance with cost-effectiveness, sensitivity, and standardisation despite the potential benefits. We talk about these restrictions and potential solutions. In conclusion, liquid biopsies revolutionise personalised therapies and cancer diagnostics by providing a real-time, non-invasive tool for characterising and monitoring tumours. It will be possible to expand the use of liquid biopsies in clinical practises by having a better understanding of their current state and predicted future developments.

引用

页数：11

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