[1] Newcastle Univ, Translat & Clin Res Inst, Fac Med Sci, Med Sch, Framlington Pl, Newcastle Upon Tyne NE2 4HH, England
[2] Newcastle Univ, Northern Ctr Mood Disorders, Wolfson Res Ctr, Newcastle Upon Tyne NE4 5PL, England
[3] St Nicholas Hosp, Cumbria Northumberland Tyne & Wear NHS Fdn Trust, Jubilee Rd, Newcastle Upon Tyne NE3 3XT, England
[4] Newcastle Upon Tyne Hosp NHS Fdn Trust, Freeman Hosp, Newcastle Cardiovasc Trials & Res, Educ Ctr,Cardiovasc Res, Room 122F, Newcastle Upon Tyne NE7 7DN, England
[5] Freeman Rd Hosp, Dept Cardiol, Newcastle Upon Tyne NE7 7DN, England
[6] Newcastle Univ, Biosci Inst, Fac Med Sci, Catherine Cookson Bldg, Newcastle Upon Tyne NE2 4HH, England
[7] Newcastle Upon Tyne Hosp NHS Fdn Trust, NIHR Newcastle Biomed Res Ctr, Campus Ageing & Vital,Westgate Rd, Newcastle Upon Tyne NE4 5PL, England
[8] Newcastle Upon Tyne Hosp NHS Fdn Trust, NIHR Newcastle Clin Res Facil, Campus Ageing & Vital,Westgate Rd, Newcastle Upon Tyne NE4 5PL, England
[9] Newcastle Univ, Populat Hlth Sci Inst, Fac Med Sci, Baddiley Clark Bldg, Newcastle Upon Tyne NE2 4AX, England
[10] Newcastle Univ, Wolfson Res Ctr, Newcastle Upon Tyne NE4 5PL, England