Photocatalysed Synthesis and Structure Activity Evaluation of Cyclohexyloxyphenethylpyridinones as Potent HIV-1 Inhibitor

被引：20
作者：
Srivastava, Vishal [1 ]
Tivari, Shraddha [1 ]
Singh, Pravin K. [1 ]
Singh, Praveen P. [2 ]
机构：
[1] Univ Allahabad, CMP Degree Coll, Dept Chem, Prayagraj 211002, India
[2] United Coll Engn & Res, Dept Chem, Prayagraj 211010, India
来源：
CATALYSIS LETTERS | 2024年 / 154卷 / 03期
关键词：
Photoredox; Visible light; HIV-1; One-pot; Pyridinones; LIGHT-INDUCED SYNTHESIS; IN-VITRO EVALUATION; REVERSE-TRANSCRIPTASE; TRANSITION-METAL; NONNUCLEOSIDE INHIBITORS; PHOTOREDOX CATALYSIS; FACILE SYNTHESIS; HIGHLY POTENT; IDENTIFICATION; DIASTEREOMERS;
D O I：
10.1007/s10562-023-04345-8
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A visible light promoted, photoredox catalysed, green one-pot approach for the synthesis of cyclohexyloxyphenethylpyridinoneshas been developed. New synthetic approach for the preparation of tailor-made synthesis of cyclohexyloxyphenethylpyridinones compounds are in extremely high demand as they display significant potent activity against wildtype HIV1 strains as well as on mutant strains. Herein, we have designed an efficient photo-induced synthetic strategy to obtain the target compound with higher yield.
引用
收藏
页码：771 / 779
页数：9
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