Phototherapy and Mechanism Exploration of Biofilm and Multidrug-Resistant Helicobacter pylori by Bacteria-Targeted NIR Photosensitizer

被引：14

作者：

Qiao, Yanqi ^{[1
]}

Ma, Yan ^{[1
]}

Tong, Yue ^{[1
]}

Liu, Wenting ^{[1
]}

Wang, Shuo ^{[1
]}

Zheng, Ying ^{[1
,2
]}

Men, Changjun ^{[3
]}

Yu, Jie ^{[4
]}

Pan, Jie ^{[5
]}

Wan, Dong ^{[5
]}

Yin, Yongmei

Zhao, Xiujie ^{[1
]}

Xi, Rimo ^{[1
]}

Meng, Meng ^{[1
]}

机构：

[1] Nankai Univ, State Key Lab Med Chem Biol, Coll Pharm, Tianjin 300350, Peoples R China

[2] Univ Macau, State Key Lab Qual Res, Chinese Med Inst, Chinese Med Sci, Ave da Univ, Macau 999078, Peoples R China

[3] Tianjin First Cent Hosp, Tianjin 300192, Peoples R China

[4] Yunnan Univ Chinese Med, Coll Pharmaceut Sci, State Key Lab Southern Med Utilizat, Kunming 650500, Yunnan, Peoples R China

[5] Tiangong Univ, Sch Chem Engn & Technol, Tianjin 300387, Peoples R China

来源：

SMALL | 2023年 / 19卷 / 04期

基金：

对外科技合作项目（国际科技项目）; 中国国家自然科学基金;

关键词：

biofilms; Guanidinium; helicobacter pylori; multidrug-resistant (MDR); phototherapy;

D O I：

10.1002/smll.202205248

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Helicobacter pylori (H. pylori) infection has been the leading cause of gastric cancer development. In recent years, the resistance of H. pylori against antibiotic treatment has been a great challenge for most countries worldwide. Since biofilm formation is one of the reasons for the antibiotic resistance of H. pylori, and phototherapy has emerged as a promisingly alternative antibacterial treatment, herein the bacteria-targeted near-infrared (NIR) photosensitizer (T780T-Gu) by combining positively-charged guanidinium (Gu) with an efficient phototherapeutic agent T780T is developed. The proposed molecule T780T-Gu exhibits synergistic photothermal therapy/photodynamic therapy effect against both H. pylori biofilms and multidrug-resistant (MDR) clinical strains. More importantly, the phototherapy mechanism of T780T-Gu acquired by the RNA-seq analysis indicates that structural deficiency as well as a decrease in metabolism and defense activity are the possible reasons for the efficient H. pylori phototherapy.

引用

页数：10

共 27 条

[1] Dynamic Constitutional Frameworks as Antibacterial and Antibiofilm Agents [J].

Diaconu, Andrei ;

Coenye, Tom ;

Barboiu, Mihail ;

Vincent, Stephane P. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 60 (41) :22505-22512

[2] Positively Charged Nanoaggregates Based on Zwitterionic Pillar[5]arene that Combat Planktonic Bacteria and Disrupt Biofilms [J].

Gao, Lingyan ;

Li, Mingjun ;

Ehrmann, Svenja ;

Tu, Zhaoxu ;

Haag, Rainer .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 58 (11) :3645-3649

[3] Helicobacter pylori Biofilm-Related Drug Resistance and New Developments in Its Anti-Biofilm Agents [J].

Hou, Chong ;

Yin, Fangxu ;

Wang, Song ;

Zhao, Ailing ;

Li, Yingzi ;

Liu, Yipin .

INFECTION AND DRUG RESISTANCE, 2022, 15 :1561-1571

[4] Rhamnolipid-assisted black phosphorus nanosheets with efficient isolinderalactone loading against drug resistant Helicobacter pylori [J].

Huang, Yanqiang ;

Li, Rujia ;

Dai, Yuanyuan ;

Qin, Chun ;

He, Jikai ;

Yang, Shixian ;

Wang, Tengqi ;

Su, Yujie ;

Jia, Lizhou ;

Zhao, Wei .

MATERIALS & DESIGN, 2022, 216

[5] Helicobacter pylori-targeting multiligand photosensitizer for effective antibacterial endoscopic photodynamic therapy [J].

Im, Byeong Nam ;

Shin, Heejun ;

Lim, Byoungjun ;

Lee, Jonghwan ;

Kim, Kyoung Sub ;

Park, Jae Myeong ;

Na, Kun .

BIOMATERIALS, 2021, 271

[6] A guanidinium-rich polymer as a new universal bioreceptor for multiplex detection of bacteria from environmental samples [J].

Kim, Sangsik ;

Romero-Lozano, Anakaren ;

Hwang, Dong Soo ;

Yoon, Jeong-Yeol .

JOURNAL OF HAZARDOUS MATERIALS, 2021, 413

[7] Rationally designed Ru(II)-metallacycle chemophototheranostic that emits beyond 1000 nm [J].

Li, Chonglu ;

Xu, Yuling ;

Tu, Le ;

Choi, Minhyeok ;

Fan, Yifan ;

Chen, Xiaoqiang ;

Sessler, Jonathan L. ;

Kim, Jong Seung ;

Sun, Yao .

CHEMICAL SCIENCE, 2022, 13 (22) :6541-6549

[8] Clinical development and potential of photothermal and photodynamic therapies for cancer [J].

Li, Xingshu ;

Lovell, Jonathan F. ;

Yoon, Juyoung ;

Chen, Xiaoyuan .

NATURE REVIEWS CLINICAL ONCOLOGY, 2020, 17 (11) :657-674

[9] Exploration of the molecular mechanisms underlying the antibiotic resistance of Helicobacter pylori: A whole-genome sequencing-based study in Southern China [J].

Li, Ying ;

Huang, Zhixin ;

Shang, Yanyan ;

Xie, Xinqiang ;

Yang, Runshi ;

Chen, Huizhen ;

Wang, Zhi ;

Xue, Liang ;

Pang, Rui ;

Zhang, Jumei ;

Ding, Yu ;

Chen, Moutong ;

Wang, Juan ;

Chen, Jianhui ;

Wu, Qingping .

HELICOBACTER, 2022, 27 (02)

[10] Near-Infrared Light Triggered Phototherapy and Immunotherapy for Elimination of Methicillin-Resistant Staphylococcus aureus Biofilm Infection on Bone Implant [J].

Li, Yuan ;

Liu, Xiangmei ;

Li, Bo ;

Zheng, Yufeng ;

Han, Yong ;

Chen, Da-Fu ;

Yeung, Kelvin Wai Kwok ;

Cui, Zhenduo ;

Liang, Yanqin ;

Li, Zhaoyang ;

Zhu, Shengli ;

Wang, Xianbao ;

Wu, Shuilin .

ACS NANO, 2020, 14 (07) :8157-8170

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