Synthesis of 1H-Pyrazolo[1,2-b]Phthalazine-5,10-Dione and 1H-Pyrazolo[1,2-a]Pyridazine-5,8-Dione Derivatives by Bovine Serum Albumin in Water

被引：7

作者：

Farahanipour, Alireza ^{[1
]}

Bavandi, Hossein ^{[1
]}

Shahedi, Mansour ^{[1
]}

Habibi, Zohreh ^{[1
]}

机构：

[1] Shahid Beheshti Univ, Fac Chem, Dept Organ Chem, Tehran 1983969411, Iran

来源：

POLYCYCLIC AROMATIC COMPOUNDS | 2023年 / 43卷 / 08期

关键词：

Green catalyst; BSA; 1H-pyrazolo[1; 2-b]phthalazine-5; 10-dione; Knoevenagel reaction; POT 4-COMPONENT SYNTHESIS; CATALYZED ONE-POT; GREEN SYNTHESIS; EFFICIENT CATALYST; IONIC LIQUID; NANOPARTICLES; ALDEHYDES; SYSTEM;

D O I：

10.1080/10406638.2022.2128829

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bovine Serum Albumin (BSA) was used as a green, inexpensive and efficient biocatalyst, for synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione and 1H-pyrazolo[1,2-a]pyridazine-5,8-dione derivatives through a one-pot three component reaction between phthalhydrazide or maleic hydrazide, Aryl aldehydes, and malononitrile in good to excellent yield (73-93%). The remarkable features of this approach include green catalyst, no organic solvent, metal-free, mild reaction, easy work-up and good functional group tolerance.

引用

页码：7042 / 7051

页数：10

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