Mesenchymal Stromal Cells and their EVs as Potential Leads for SARS-CoV2 Treatment

被引：1

作者：

Kia, Vahid ^{[1
]}

Eshaghi-gorji, Reza ^{[2
]}

Mansour, Reyhaneh Nassiri ^{[2
]}

Hassannia, Hadi ^{[3
,4
]}

Hasanzadeh, Elham ^{[5
]}

Gheibi, Mobina ^{[2
]}

Mellati, Amir ^{[5
]}

Enderami, Seyed Ehsan ^{[6
,7
]}

机构：

[1] Shahroud Univ Med Sci, Sch Med, Dept Med Biotechnol, Shahroud, Iran

[2] Mazandaran Univ Med Sci, Student Res Comm, Sari, Iran

[3] Mazandaran Univ Med Sci, Sch Med, Immunogenet Res Ctr, Sari, Iran

[4] Mazandaran Univ Med Sci, Amol Fac Paramed Sci, Sari, Iran

[5] Mazandaran Univ Med Sci, Sch Adv Technol Med, Dept Tissue Engn & Regenerat Med, Sari, Iran

[6] Mazandaran Univ Med Sci, Mol & Cell Biol Res Ctr, Fac Med, Sari, Iran

[7] Mazandaran Univ Med Sci, Fac Adv Technol Med, Dept Med Biotechnol, Sari, Iran

来源：

CURRENT STEM CELL RESEARCH & THERAPY | 2023年 / 18卷 / 01期

关键词：

Betacoronavirus; mesenchymal Stromal Cells; COVID-19; nanoparticles; SARS-CoV-2; therapeutic Capabilities; INSULIN-PRODUCING CELLS; STEM-CELLS; EXTRACELLULAR VESICLES; BONE-MARROW; EXOSOME ISOLATION; SARS CORONAVIRUS; INJURY; MICROVESICLES; GENERATION; DELIVERY;

D O I：

10.2174/1574888X17666220426115831

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

In December 2019, a betacoronavirus was isolated from pneumonia cases in China and rapidly turned into a pandemic of COVID-19. The virus is an enveloped positive-sense ssRNA and causes a severe respiratory syndrome along with a cytokine storm, which is the main cause of most complications. Therefore, treatments that can effectively control the inflammatory reactions are necessary. Mesenchymal Stromal Cells and their EVs are well-known for their immunomodulatory effects, inflammation reduction, and regenerative potentials. These effects are exerted through paracrine secretion of various factors. Their EVs also transport various molecules such as microRNAs to other cells and affect recipient cells' behavior. Scores of research and clinical trials have indicated the therapeutic potential of EVs in various diseases. EVs also seem to be a promising approach for severe COVID-19 treatment. EVs have also been used to develop vaccines since EVs are biocompatible nanoparticles that can be easily isolated and engineered. In this review, we have focused on the use of Mesenchymal Stromal Cells and their EVs for the treatment of COVID-19, their therapeutic capabilities, and vaccine development.

引用

页码：35 / 53

页数：19

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