Bioactive lipids as biomarkers of adverse reactions associated with apheresis platelet concentrate transfusion

被引:7
作者
Duchez, Anne-Claire [1 ,2 ]
Fauteux-Daniel, Sebastien [1 ,2 ]
Sut, Caroline [1 ]
Ebermeyer, Theo [2 ]
Heestermans, Marco [1 ,2 ]
Arthaud, Charles-Antoine [1 ,2 ]
Eyraud, Marie-Ange [1 ,2 ]
Prier, Amelie [1 ,2 ]
Audoux, Estelle [1 ,2 ]
Bertrand-Michel, Justine [3 ,4 ]
Payrastre, Bernard [4 ,5 ]
Garraud, Olivier [2 ]
Boilard, Eric [6 ,7 ,8 ]
Hamzeh-Cognasse, Hind [2 ]
Cognasse, Fabrice [1 ,2 ]
机构
[1] Etab Francais Sang Auvergne Rhone Alpes, St Etienne, France
[2] Univ St Etienne, SAINBIOSE, INSERM, St Etienne, France
[3] Natl Infrastruct Metabol & Flux, MetaboHUB MetaToul, Toulouse, France
[4] Univ Toulouse III Paul Sabatier UPS, Univ Toulouse, Inserm, I2MC, Toulouse, France
[5] ToNIC Toulouse NeuroImaging Ctr, INSERM UMR, Toulouse, France
[6] Ctr Rech CHU Quebec, Dept Infect Dis & Immun, Quebec City, PQ, Canada
[7] Univ Laval, Quebec City, PQ, Canada
[8] Ctr Rech ARThr, Quebec City, PQ, Canada
来源
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
关键词
inflammation; platelet; transfusion; lipid mediator; adverse reaction (AR); ACUTE LUNG INJURY; WHOLE-BLOOD; ACID; STORAGE; PLASMA; IDENTIFICATION; METABOLISM; DISEASE; LEVEL;
D O I
10.3389/fimmu.2023.1031968
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Platelet concentrate (PC) transfusion seeks to provide haemostasis in patients presenting severe central thrombocytopenia or severe bleeding. PCs may induce adverse reactions (AR) that can occasionally be severe (SAR). PCs contain active biomolecules such as cytokines and lipid mediators. The processing and storage of PCs creates so-called structural and biochemical storage lesions that accumulate when blood products reach their shelf life. We sought to investigate lipid mediators as bioactive molecules of interest during storage and review associations with adverse reactions post-transfusion. To facilitate understanding, we focused on single donor apheresis (SDA) PCs with approximately 31.8% of PCs being delivered in our setting. Indeed, pooled PCs are the most widely transfused products, but the study of a single donor lipid mediator is easier to interpret. We are investigating key lipid mediators involved in AR. Adverse reactions were closely monitored in accordance with current national and regional haemovigilance protocols. Residual PCs were analysed post-transfusion in a series of observations, both with and without severe reactions in recipients. A decrease in the lysophosphatidylcholine species to produce the lysophosphatidic acid species has been observed during storage and in the case of AR. Lysophosphatidic acid increased with primarily platelet-inhibitor lipids. Anti-inflammatory platelet-induced inhibition lipids were weakly expressed in cases of severe adverse reactions. We therefore propose that a decrease in lysophosphatidylcholine and an increase in lysophosphatidic acid can prospectively predict serious adverse transfusion reactions.
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页数:14
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