Immunogenicity of an Additional mRNA-1273 SARS-CoV-2 Vaccination in People With HIV With Hyporesponse After Primary Vaccination

被引：14

作者：

Jongkees, Marlou J. ^{[1
,2
]}

Geers, Daryl ^{[3
]}

Hensley, Kathryn S. ^{[1
,2
]}

Huisman, Wesley ^{[4
]}

GeurtsvanKessel, Corine H. ^{[3
]}

Bogers, Susanne ^{[3
]}

Gommers, Lennert ^{[3
]}

Papageorgiou, Grigorios ^{[5
]}

Jochems, Simon P. ^{[4
]}

den Hollander, Jan G. ^{[6
]}

Schippers, Emile F. ^{[7
,8
]}

Ammerlaan, Heidi S. M. ^{[9
]}

Bierman, Wouter F. W. ^{[10
]}

van der Valk, Marc ^{[11
,12
]}

Berrevoets, Marvin A. H. ^{[13
]}

Soetekouw, Robert ^{[14
]}

Langebeek, Nienke ^{[15
]}

Bruns, Anke H. W. ^{[16
]}

Leyten, Eliane M. S. ^{[17
]}

Sigaloff, Kim C. E. ^{[12
]}

van Vonderen, Marit G. A. ^{[18
]}

Delsing, Corine E. ^{[19
]}

Branger, Judith ^{[20
]}

Katsikis, Peter D. ^{[21
]}

Mueller, Yvonne M. ^{[21
]}

de Vries, Rory D. ^{[3
]}

Rijnders, Bart J. A. ^{[1
,2
]}

Brinkman, Kees ^{[22
]}

Rokx, Casper ^{[1
,2
]}

Roukens, Anna H. E. ^{[7
]}

机构：

[1] Erasmus MC, Dept Internal Med, Sect Infect Dis, Rotterdam, Netherlands

[2] Erasmus MC, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands

[3] Erasmus MC, Dept Virosci, Rotterdam, Netherlands

[4] Leiden Univ, Ctr Infect Dis, Med Ctr, Dept Parasitol, Leiden, Netherlands

[5] Erasmus MC, Dept Biostat, Rotterdam, Netherlands

[6] Maasstad Hosp, Dept Internal Med, Rotterdam, Netherlands

[7] Leiden Univ, Med Ctr, Dept Infect Dis, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands

[8] Haga Teaching Hosp, Dept Internal Med, The Hague, Netherlands

[9] Catharina Hosp, Dept Internal Med, Eindhoven, Netherlands

[10] Univ Med Ctr Groningen, Dept Internal Med & Infect Dis, Groningen, Netherlands

[11] DC Klin, Dept Internal Med & Infect Dis, Amsterdam, Netherlands

[12] Amsterdam Univ Med Ctr, Amsterdam Inst Infect & Immun, Dept Infect Dis, Amsterdam, Netherlands

[13] Elisabeth Tweesteden Hosp, Dept Internal Med, Tilburg, Netherlands

[14] Spaarne Gasthuis, Dept Internal Med & Infect Dis, Haarlem, Netherlands

[15] Rijnstate Hosp, Dept Internal Med & Infect Dis, Arnhem, Netherlands

[16] Univ Med Ctr Utrecht, Dept Internal Med & Infect Dis, Utrecht, Netherlands

[17] Haaglanden Med Ctr, Dept Internal Med & Infect Dis, The Hague, Netherlands

[18] Med Ctr Leeuwarden, Dept Internal Med, Leeuwarden, Netherlands

[19] Med Spectrum Twente, Dept Internal Med & Infect Dis, Enschede, Netherlands

[20] Flevo Hosp, Dept Internal Med, Almere, Netherlands

[21] Erasmus MC, Dept Immunol, Rotterdam, Netherlands

[22] OLVG Hosp, Dept Internal Med & Infect Dis, Amsterdam, Netherlands

来源：

JOURNAL OF INFECTIOUS DISEASES | 2023年 / 227卷 / 05期

关键词：

COVID-19; HIV; SARS-CoV-2; vaccines; additional dose; nonresponder; INFECTION; SAFETY;

D O I：

10.1093/infdis/jiac451

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. The COVIH study is a prospective coronavirus disease 2019 (COVID-19) vaccination study in 1154 people with HIV (PWH), of whom 14% showed reduced antibody levels after primary vaccination. We evaluated whether an additional vaccination boosts immune responses in these hyporesponders. Methods. The primary end point was the increase in antibodies 28 days after additional mRNA-1273 vaccination. Secondary end points included neutralizing antibodies, S-specific T-cell and B-cell responses, and reactogenicity. Results. Of the 66 participants, 40 previously received 2 doses ChAdOx1-S, 22 received 2 doses BNT162b2, and 4 received a single dose Ad26.COV2.S. The median age was 63 years (interquartile range [IQR], 60-66), 86% were male, and median CD4(+) T-cell count was 650/mu L (IQR, 423-941). The mean S1-specific antibody level increased from 35 binding antibody units (BAU)/mL (95% confidence interval [CI], 24-46) to 4317 BAU/mL (95% CI, 3275-5360) (P<.0001). Of all participants, 97% showed an adequate response and the 45 antibody-negative participants all seroconverted. A significant increase in the proportion of PWH with ancestral S-specific CD4(+) T cells (P=.04) and S-specific B cells (P=.02) was observed. Conclusions. An additional mRNA-1273 vaccination induced a robust serological response in 97% of PWH with a hyporesponse after primary vaccination.

引用

页码：651 / 662

页数：12

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